Eric Yixin Yang

  • Position:
    Professor of Biology
  • College:
    College of Science, Mathematics and Technology
  • Office:
    CSMT 504

Education background

Ph.D. in Molecular Biology, Microbiology and Biochemistry
Southern Illinois University, USA

M.S. in Computer Science
Southern Illinois University, USA

B.S. in Clinical Medicine
Dalian Medical University, China

Courses teaching in WKU

BIO1000 Principles of Biology

STM5010 Molecular and Cell Biology (Graduate level)

Biography (required for all faculty)

Eric Yixin Yang, Ph.D., is a Doctor of Molecular Biology, Microbiology, and Biochemistry from Southern Illinois University. He is a member of the American Association for Cancer Research and serves as a board member for the Zhejiang Province Bioinformatics Society. Previously, he held positions as a full professor in the Department of Biology at Emporia State University in Kansas, where he also served as the Graduate Program Coordinator. Additionally, he served as the Acting Dean of the Graduate College and Assistant Vice President for Academic Affairs at Kean University in the United States. Currently, Dr. Yang holds the position of Vice Chancellor for Academic Affairs at Wenzhou-Kean University, where he brings with him a wealth of management and research experience. He has a strong track record of academic achievement, with 29 scholarly articles published in prestigious international journals on topics related to cancer and medicine. Furthermore, Dr. Yang has received research funding from various institutions, including the National Natural Science Foundation of China, the International Research Center for Bioinformatics at the Zhejiang Provincial Department of Science and Technology, and the Key Laboratory of Applied Biomedical and Biopharmaceutical Informatics in Wenzhou. He serves as the principal investigator for these organizations, leading significant research projects in the field of bioinformatics.

Research interests (for tenure-track/tenured faculty and lecturers who are/were active in research and scholarly activities)

cocktail therapy combining heat shock protein inhibitors and autophagy inhibitors against melanoma; roles of antioxidants in melanoma growth and invasiveness and drug resistance to chemotherapy; the roles of microRNAs in human malignant melanoma and microRNA-based therapeutics against melanoma; the pharmacological effects of phytochemicals on human malignant melanoma; the differential response of P53 network at different oncogenic mutation context; utilization of CRISPR-dCas9 system to regulate miRNA expressions.

Selected Peer-reviewed Publications

(1) S. Deng, X. Tian, R. Belshaw, J. Zhou, S. Zhang, Y. Yang, C. Huang, H. Qiu (2022). An RNA-Seq analysis of coronavirus in the skin of the Pangolin: Implications for its conservation. Biological Conservation. (in press)

(2) Hu C, Huang Y, Luo P, Yang Y (2021). Effect of antioxidants coenzyme Q10 and β-carotene on the cytotoxicity of vemurafenib against human malignant melanoma. Oncology Letters 2021 Mar;21(3):208. doi: 10.3892/ol.2021.12469. Epub 2021 Jan 14. PMID: 33574947; PMCID: PMC7816282 (correspondence author)

(3) Wong A, Hu N, Tian X, Yang Y, Gehring C. Nitric oxide sensing revisited. Trends Plant Sci. 2021 Sep;26(9):885-897. doi: 10.1016/j.tplants.2021.03.009. Epub 2021 Apr 16. PMID: 33867269.

(4) Wong A, Tian X, Yang Y, Gehring C (2021). Identification of potential nitric oxide-sensing proteins using the H-NOX motif. Molecular Plant 2021 Feb 1;14(2):195-197. doi: 10.1016/j.molp.2020.11.015. Epub 2020 Nov 27. PMID: 33249236.

(5) W Chang, D Zheng, C Zhao, Y Yang (2019). Photocatalytic Activity of MOF-derived Cu 2 O/Cu/C/Ag Porous Composites. South African Journal of Chemistry 72 (1), 10-15

(6) Yang Y, Alderman C, Sehlaoui A, Xiao Y, Wang W. MicroRNAs as Immunotherapy Targets for Treating Gastroenterological Cancers. Can J Gastroenterol Hepatol. 2018 Jun 26;2018:9740357. doi: 10.1155/2018/9740357. PMID: 30046565 (first and correspondence author) 

(7) Wang X, Yang YE, Jia L, Chen Q (2018). Gastroenterological Cancer and Immunotherapy. Canadian Journal of Gastroenterology and Hepatology. PMID: 30073155. doi: 10.1155/2018/4697670

(8) Yang, G., Yan, Y., Yang, Y (2017). Vitamin C at high concentrations induces cytotoxicity in malignant melanoma but promotes tumor growth at low concentrations. Molecular Carcinogenesis. 2017 Aug;56(8):1695-1676; DOI: 10.1002/mc.22654, PMID: 28370562 (correspondence author)

(9) Zhao Y, Chen R, Yang Y (2017). α-pinene inhibits human prostate cancer growth in a mouse xenograft model. Chemotherapy Oct 26;63(1):1-7 PMID: 29069647

(10) Qian, H., Yang, C., Yang, Y (2017). MicroRNA 26a Inhibits Proliferation and Metastasis of Human Malignant Melanoma Cells and It Targets on MITF Gene. Cell Death Discovery. 2017; 3, 17028.  PMCID: PMC5502303 (correspondence author)

(11) Hu C, Zhao Y, Yang Y (2017). Synergism of Dam, MutH, and MutS in methylation-directed mistmatch repair in Escherichia coli. Mutation Research 2017; 797:31-33. PMID: 28107644 (correspondence author)

(12) Alderman C, Yang Y. (2016). The Anti-melanoma activity and oncogenic targets of hsa-miR-15a-5p. RNA and Disease. 2016; 3: e1450. doi: 10.14800/rd.1450 (correspondence author)

(13) Alderman C, Sehlaoui A., Xiao Z, Yang Y. (2016). MicroRNA-15a inhibits the growth and invasiveness of malignant melanoma and directly targets on CDCA4 gene. Tumor Biology. 2016; 37(10): 13941-13950. PMID: 27492455  (correspondence author)

(14) Yunqi Zhao, Ran Chen, Yun Wang, Wei Wang, Yixin Yang. (2016) In Vitro and In Vivo Efficacy Studies of Lavender angustifolia Essential Oil and Its Active Constituents on the Proliferation of Human Prostate Cancer. Integrative Cancer Therapies. pii: 1534735416645408. PMID:27151584 (correspondence author)

(15) Li Z, Wang XP, Lin HP, Xu B, Zhao Q, Yang YX, Wang ZR (2015). Anti-tumor immunity elicited by cross-linking vaccine heat shock protein 72 and alpha-fetoprotein epitope peptide. Neoplasma. 2015;62(5):713-21. doi: 0.4149/neo_2015_085. PMID: 26278150

(16) Wang, XP, Lin, HP, Xu, B, Fang, JG, Yang, YX (2014). Chaperoned Function of HSP72 in Hepatocellular Carcinomas. 2014 IEEE Workshop on Electronics, Computer and Applications

(17) Wang X, Wang Q, Lin H, Sun L, Yang EY (2013). HSP72 and gp96 in gastroenterological cancers. Clin Chim Acta. Vol 417: 73-79. PMID: 23266770    

(18) Wang X, Wang Q, Lin H, Wang Y, Yang Y. (2013). Glycoprotein 96 and α-fetoprotein crossing-linking complex elicited specific anti-tumor immunity. Cancer Biotherapy and Radiopharmaceuticals. Vol 28 (5):406-14. PMID: 23484810

(19) Ma, X., Yang, Y., Wang, Y., Lv, G. (2010) Small Interfering RNA-Directed Knockdown of S100A4 Decreases Proliferation and Invasiveness of Osteosarcoma Cells. Cancer Letters Vol. 299: 171-181

(20) Ma, X., Yang, Y., Wang, Y., An, G., and Lv, G. (2012) RNAi inhibit the expression of S100A4 gene and its effect on invasion and metastasis ability of osteosarcoma cell in vitro. Journal of Dalian Medical University. Vol. 34, No. 1:36-41

(21) Xiao Zhao-yang, Wang Shou-ping, Yang Yi-xin, Ning Yanghong, Zou Jianfei (2010) Mechanism of the Preconditioning Protection against Anoxia-reoxygenation Injury of Neonatal Rat Cardiomyocytes.  Chinese Journal of Anesthesiology Vol. 30:11:1388-90. (co-correspondence author)

(22) Wolyniak M.J., Alvarez C.J., Chandrasekaran V., Grana T.M., Holgado A., Jones C.J., Morris R.W., Pereira A.L., Stamm J., Washington T.M., and Yang Y.  (2010). Building Better Scientists Through Cross-disciplinary Collaboration in Synthetic Biology: A Meeting Report from the Genome Consortium for Active Teaching (GCAT) Workshop 2010. Cell Biology Education-Life Sciences Education 9(4):399-404.

(23)  Schrock J. R. and Yang, Y (2007). The Growing Problem of Plagiarism and the Correct Use of Science Citation. Biology Teaching Vol. 32, No.7 (co-first author)

(24)  Guo Wei-jia, Miao Zhuang, Xiao Zhao-yang, Yang Yi-xin. (2007) Effects of Dexamethasone on Neuromuscular Blocking Efficiency of Atracurium. Journal of Dalian Medical University. Vol. 29, No. 2

(25) Guo Wei-jia, Xiao Zhao-yang, Yang Yi-xin. (2007) The Effectiveness of Transdermal Fentanyl Combined with Clodine for Pain Control of Acute Herpes Zoster. Journal of Dalian Medical University. Vol. 29, No. 3 

(26) B. Gupta, S. Rahimi, and Y. Yang. (2007) A Novel Rollback Mechanism for Performance Enhancement of Asynchronous Checkpointing and Recovery, Informatica, 31: 1-13 (co-first author)

(27) Gupta, B., Yang, Y., Rahimi, S., and Vemuri, A. (2006) A High-Performance Recovery Algorithm for Distributed Systems. ISCA 21st International Conference on Computers and Their Applications, March 23-25, 2006, Seattle, Washington, U.S.A. Editor: J. Jackson, ISBN:  1-880843-58-7 (co-first author)

(28) Yang, Y. and D. Fix. (2006) Genetic Analysis of the Anti-mutagenic Effect of Genistein in Escherichia coli. Mutation Research. 600: 193- 206 (first author)

(29) Yang, Y. and D. Fix. (2001) Reduction of ENU-induced Transversion Mutations by the Isoflavone Genistein in Escherichia coli. Mutation Research. 8; 479(1-2):63-70. (first author)

Research Grants

(1) Wenzhou City Applied Biomedical and Biopharmaceutical Informatics Key Lab Development Grant, Wenzhou Municipal Government (2021): 800,000 RMB ($124,000), Principal Investigator

(2) Zhejiang Province Bioinformatics International Research Collaboration Center Award, Department of Science and Technology, Zhejiang province (2020): 1,000,000 RMB ($154,000), Principal Investigator

(3) STEM Education in the state of New Jersey of the United States and Zhejiang Province of China, the Association of Science and Technology of Wenzhou City: (2019): 20,000 RBM ($3,100), Principal Investigator

(4) Kansas IDeA Network of Biomedical Research Excellence Award, an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health (K-INBRE), Core Facility grant (2013, 2014, and 2016)

2016: $10,000, Principal Investigator

2014: $9,970, Principal Investigator

2013: $24,500, Principal Investigator

(5) International Research Collaboration Grant of National Natural Science Foundation of China (2013): $7,000, Principal Investigator

(6) Kansas IDeA Network of Biochemical Research Excellence (K-INBRE) Research Grant and Institution Matching Grant (2011): $80,000, Principal Investigator

(7) Kansas IDeA Network of Biomedical Research Excellence (K-INBRE) Summer Scholar Awards (2008, 2009, 2011, 2013, 2015, 2016): $42,000, Principal Investigator

(8) Kansas IDeA Network of Biomedical Research Excellence (K-INBRE) Scholar Award (2007-2017): $15,250, Principal Investigator

(9) Recruiting Package Research Grant of Kansas IDeA Network of Biochemical Research Excellence (K-INBRE) (2005-2006): $35,000, Principal Investigator

(10) Faculty Research and Creativity Grant of Emporia State University 2006-2017: $149,790, Principal Investigator

(11) International Travel Grant of Emporia State University (2007-2016): $10,000

(12) Faculty grant writing incentive grant (2011): $2,000

(13) Faculty incentive grant (2009 - 2010): $2,000

(14) Academic Enhancement Grant of Emporia State University (2009 - 2010): $2,000