Ph.D. in Molecular Biology, Microbiology and Biochemistry
Southern Illinois University, USA

M.S. in Computer Science
Southern Illinois University, USA

B.S. in Clinical Medicine
Dalian Medical University, China

BIO1000 Principles of Biology

STM5010 Molecular and Cell Biology (Graduate level)

杨毅欣，南伊利诺伊大学分子生物学、微生物学和生物化学博士，美国癌症研究协会会员，浙江省生物信息学学会理事。曾担任堪萨斯州恩波里亚州立大学生物系正教授、研究生项目主管，美国肯恩大学研究生院代理院长兼学术副校长。现担任温州肯恩大学学术副校长，拥有丰富的管理与科研经验。在国际权威期刊上发表了29篇关于癌症、医药等领域的学术论文。获得国家自然科学基金、浙江省科技厅生物信息学国际科研合作中心、温州市应用生物医学和生物制药信息学重点实验室等14所科研机构资助并担任主要研究员。

cocktail therapy combining heat shock protein inhibitors and autophagy inhibitors against melanoma; roles of antioxidants in melanoma growth and invasiveness and drug resistance to chemotherapy; the roles of microRNAs in human malignant melanoma and microRNA-based therapeutics against melanoma; the pharmacological effects of phytochemicals on human malignant melanoma; the differential response of P53 network at different oncogenic mutation context; utilization of CRISPR-dCas9 system to regulate miRNA expressions.

(1) S. Deng, X. Tian, R. Belshaw, J. Zhou, S. Zhang, Y. Yang, C. Huang, H. Qiu (2022). An RNA-Seq analysis of coronavirus in the skin of the Pangolin: Implications for its conservation. Biological Conservation. (in press)

(2) Hu C, Huang Y, Luo P, Yang Y (2021). Effect of antioxidants coenzyme Q10 and β-carotene on the cytotoxicity of vemurafenib against human malignant melanoma. Oncology Letters 2021 Mar;21(3):208. doi: 10.3892/ol.2021.12469. Epub 2021 Jan 14. PMID: 33574947; PMCID: PMC7816282 (correspondence author)

(3) Wong A, Hu N, Tian X, Yang Y, Gehring C. Nitric oxide sensing revisited. Trends Plant Sci. 2021 Sep;26(9):885-897. doi: 10.1016/j.tplants.2021.03.009. Epub 2021 Apr 16. PMID: 33867269.

(4) Wong A, Tian X, Yang Y, Gehring C (2021). Identification of potential nitric oxide-sensing proteins using the H-NOX motif. Molecular Plant 2021 Feb 1;14(2):195-197. doi: 10.1016/j.molp.2020.11.015. Epub 2020 Nov 27. PMID: 33249236.

(5) W Chang, D Zheng, C Zhao, Y Yang (2019). Photocatalytic Activity of MOF-derived Cu 2 O/Cu/C/Ag Porous Composites. South African Journal of Chemistry 72 (1), 10-15

(6) Yang Y, Alderman C, Sehlaoui A, Xiao Y, Wang W. MicroRNAs as Immunotherapy Targets for Treating Gastroenterological Cancers. Can J Gastroenterol Hepatol. 2018 Jun 26;2018:9740357. doi: 10.1155/2018/9740357. PMID: 30046565 (first and correspondence author) 

(7) Wang X, Yang YE, Jia L, Chen Q (2018). Gastroenterological Cancer and Immunotherapy. Canadian Journal of Gastroenterology and Hepatology. PMID: 30073155. doi: 10.1155/2018/4697670

(8) Yang, G., Yan, Y., Yang, Y (2017). Vitamin C at high concentrations induces cytotoxicity in malignant melanoma but promotes tumor growth at low concentrations. Molecular Carcinogenesis. 2017 Aug;56(8):1695-1676; DOI: 10.1002/mc.22654, PMID: 28370562 (correspondence author)

(9) Zhao Y, Chen R, Yang Y (2017). α-pinene inhibits human prostate cancer growth in a mouse xenograft model. Chemotherapy Oct 26;63(1):1-7 PMID: 29069647

(10) Qian, H., Yang, C., Yang, Y (2017). MicroRNA 26a Inhibits Proliferation and Metastasis of Human Malignant Melanoma Cells and It Targets on MITF Gene. Cell Death Discovery. 2017; 3, 17028.  PMCID: PMC5502303 (correspondence author)

(11) Hu C, Zhao Y, Yang Y (2017). Synergism of Dam, MutH, and MutS in methylation-directed mistmatch repair in Escherichia coli. Mutation Research 2017; 797:31-33. PMID: 28107644 (correspondence author)

(12) Alderman C, Yang Y. (2016). The Anti-melanoma activity and oncogenic targets of hsa-miR-15a-5p. RNA and Disease. 2016; 3: e1450. doi: 10.14800/rd.1450 (correspondence author)

(13) Alderman C, Sehlaoui A., Xiao Z, Yang Y. (2016). MicroRNA-15a inhibits the growth and invasiveness of malignant melanoma and directly targets on CDCA4 gene. Tumor Biology. 2016; 37(10): 13941-13950. PMID: 27492455  (correspondence author)

(14) Yunqi Zhao, Ran Chen, Yun Wang, Wei Wang, Yixin Yang. (2016) In Vitro and In Vivo Efficacy Studies of Lavender angustifolia Essential Oil and Its Active Constituents on the Proliferation of Human Prostate Cancer. Integrative Cancer Therapies. pii: 1534735416645408. PMID:27151584 (correspondence author)

(15) Li Z, Wang XP, Lin HP, Xu B, Zhao Q, Yang YX, Wang ZR (2015). Anti-tumor immunity elicited by cross-linking vaccine heat shock protein 72 and alpha-fetoprotein epitope peptide. Neoplasma. 2015;62(5):713-21. doi: 0.4149/neo_2015_085. PMID: 26278150

(16) Wang, XP, Lin, HP, Xu, B, Fang, JG, Yang, YX (2014). Chaperoned Function of HSP72 in Hepatocellular Carcinomas. 2014 IEEE Workshop on Electronics, Computer and Applications

(17) Wang X, Wang Q, Lin H, Sun L, Yang EY (2013). HSP72 and gp96 in gastroenterological cancers. Clin Chim Acta. Vol 417: 73-79. PMID: 23266770    

(18) Wang X, Wang Q, Lin H, Wang Y, Yang Y. (2013). Glycoprotein 96 and α-fetoprotein crossing-linking complex elicited specific anti-tumor immunity. Cancer Biotherapy and Radiopharmaceuticals. Vol 28 (5):406-14. PMID: 23484810

(19) Ma, X., Yang, Y., Wang, Y., Lv, G. (2010) Small Interfering RNA-Directed Knockdown of S100A4 Decreases Proliferation and Invasiveness of Osteosarcoma Cells. Cancer Letters Vol. 299: 171-181

(20) Ma, X., Yang, Y., Wang, Y., An, G., and Lv, G. (2012) RNAi inhibit the expression of S100A4 gene and its effect on invasion and metastasis ability of osteosarcoma cell in vitro. Journal of Dalian Medical University. Vol. 34, No. 1：36-41

(21) Xiao Zhao-yang, Wang Shou-ping, Yang Yi-xin, Ning Yanghong, Zou Jianfei (2010) Mechanism of the Preconditioning Protection against Anoxia-reoxygenation Injury of Neonatal Rat Cardiomyocytes.  Chinese Journal of Anesthesiology Vol. 30:11:1388-90. (co-correspondence author)

(22) Wolyniak M.J., Alvarez C.J., Chandrasekaran V., Grana T.M., Holgado A., Jones C.J., Morris R.W., Pereira A.L., Stamm J., Washington T.M., and Yang Y.  (2010). Building Better Scientists Through Cross-disciplinary Collaboration in Synthetic Biology: A Meeting Report from the Genome Consortium for Active Teaching (GCAT) Workshop 2010. Cell Biology Education-Life Sciences Education 9(4):399-404.

(23)  Schrock J. R. and Yang, Y (2007). The Growing Problem of Plagiarism and the Correct Use of Science Citation. Biology Teaching Vol. 32, No.7 (co-first author)

(24)  Guo Wei-jia, Miao Zhuang, Xiao Zhao-yang, Yang Yi-xin. (2007) Effects of Dexamethasone on Neuromuscular Blocking Efficiency of Atracurium. Journal of Dalian Medical University. Vol. 29, No. 2

(25) Guo Wei-jia, Xiao Zhao-yang, Yang Yi-xin. (2007) The Effectiveness of Transdermal Fentanyl Combined with Clodine for Pain Control of Acute Herpes Zoster. Journal of Dalian Medical University. Vol. 29, No. 3 

(26) B. Gupta, S. Rahimi, and Y. Yang. (2007) A Novel Rollback Mechanism for Performance Enhancement of Asynchronous Checkpointing and Recovery, Informatica, 31: 1-13 (co-first author)

(27) Gupta, B., Yang, Y., Rahimi, S., and Vemuri, A. (2006) A High-Performance Recovery Algorithm for Distributed Systems. ISCA 21st International Conference on Computers and Their Applications, March 23-25, 2006, Seattle, Washington, U.S.A. Editor: J. Jackson, ISBN:  1-880843-58-7 (co-first author)

(28) Yang, Y. and D. Fix. (2006) Genetic Analysis of the Anti-mutagenic Effect of Genistein in Escherichia coli. Mutation Research. 600: 193- 206 (first author)

(29) Yang, Y. and D. Fix. (2001) Reduction of ENU-induced Transversion Mutations by the Isoflavone Genistein in Escherichia coli. Mutation Research. 8; 479(1-2):63-70. (first author)

(1) Wenzhou City Applied Biomedical and Biopharmaceutical Informatics Key Lab Development Grant, Wenzhou Municipal Government (2021): 800,000 RMB ($124,000), Principal Investigator

(2) Zhejiang Province Bioinformatics International Research Collaboration Center Award, Department of Science and Technology, Zhejiang province (2020): 1,000,000 RMB ($154,000), Principal Investigator

(3) STEM Education in the state of New Jersey of the United States and Zhejiang Province of China, the Association of Science and Technology of Wenzhou City: (2019): 20,000 RBM ($3,100), Principal Investigator

(4) Kansas IDeA Network of Biomedical Research Excellence Award, an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health (K-INBRE), Core Facility grant (2013, 2014, and 2016)

2016: $10,000, Principal Investigator

2014: $9,970, Principal Investigator

2013: $24,500, Principal Investigator

(5) International Research Collaboration Grant of National Natural Science Foundation of China (2013): $7,000, Principal Investigator

(6) Kansas IDeA Network of Biochemical Research Excellence (K-INBRE) Research Grant and Institution Matching Grant (2011): $80,000, Principal Investigator

(7) Kansas IDeA Network of Biomedical Research Excellence (K-INBRE) Summer Scholar Awards (2008, 2009, 2011, 2013, 2015, 2016): $42,000, Principal Investigator

(8) Kansas IDeA Network of Biomedical Research Excellence (K-INBRE) Scholar Award (2007-2017): $15,250, Principal Investigator

(9) Recruiting Package Research Grant of Kansas IDeA Network of Biochemical Research Excellence (K-INBRE) (2005-2006): $35,000, Principal Investigator

(10) Faculty Research and Creativity Grant of Emporia State University 2006-2017: $149,790, Principal Investigator

(11) International Travel Grant of Emporia State University (2007-2016): $10,000

(12) Faculty grant writing incentive grant (2011): $2,000

(13) Faculty incentive grant (2009 - 2010): $2,000

(14) Academic Enhancement Grant of Emporia State University (2009 - 2010): $2,000