Jianliang Shen, Ph.D.

  • Position:
    Graduate Tutor
  • College:
    College of Science, Mathematics and Technology

Education

  1. 9/2010–5/2014   Ph.D., SunYat-Sen University (PI: Prof. Zongwan Mao)
  2. 9/2007-7/2010   M.S., Xiangtan University (PI: Prof. Lifeng Tan)
  3. 9/2003-7/2007   B.Eng., Hunan University of Science & Technology

Working Experience

  1. 9/2017–Present   Professor, Wenzhou Medical University
  2. 9/2017–Present   Professor, Wenzhou Institute，University of Chinese Academy of Sciences
  3. 6/2014–6/2017   Postdoctoral Fellow, Houston Methodist Research Institute (PI: Prof. Haifa Shen)
  4. 6/2012–4/2014   Research Fellow, Houston Methodist Research Institute (PI: Prof. Haifa Shen)

Research Interests and Backgrounds

I am a biologist and material scientist with a strong interest in applying micro/nano-technology platforms for cancer and other diseases drug discovery. My overall research interest is on precision medicine for human cancers, such as (1) an injectable nanoparticle generator platform for targeted delivery and in situ activation of prodrugs at the tumor lesion, (2) an inflammatory tumor vasculature-targeted delivery system for small molecule inhibitors and therapeutic siRNA, and (3) a highly potent therapeutic cancer nano-vaccine platform. A biomaterial and nanomedicine doctor by training, I have acquired strong experience in biomaterials during past years (Theranostics 2014, ACS Nano 2013, Advanced Healthcare Materials 2014, Nanoscale 2017), cancer genetics through postdoctoral training (Nature Biotechnology 2016, Materials Today 2017, Nano Letters 2017, Nanoscale 2017), and functional materials applied on medicine (Chemical Society Reviews 2018, Biomaterials 2018, Theranostics 2018, Clinical Cancer Research 2018, 2018). I have also gained extensive experience on cancer drug development with 10 years in the university and academic institute on development of novel cancer drugs. My current research is focused on development of therapeutics and technologies to advance cancer metastasis, tissue engineering, antibacterial materials and medical probes and so on. I strongly believe that different diseases should be treated differently based on their unique microenvironments and transport properties, and that nanotechnology offers a unique advantage on drug delivery to most of the illness. Recently, our studies have demonstrated that we now have powerful biomaterial systems to overcome biological barriers and effectively deliver therapeutics to such diseases (Journal of Hazardous Materials 2020, Carbohydrate Polymers 2020, ACS Applied Materials & Interfaces 2020, Chemical communications 2020, ACS Sustainable Chemistry & Engineering 2019, Iscience 2019).

Publications

  1. Zhang M., Huang Y., Pan X., Tong X., Zeng Q., Su T., Qi X., Shen, J.*, Polydopamine-incorporated dextran hydrogel drug carrier with tailorable structure for wound healing, Carbohydrate Polymers, 2020, 117213.
  2. Su, T., Zhang, M., Pan, W., Qian, Y., Zhou, Z., He, X., Shen, L., Dong, W., Qi, X.*, Shen, J.*, Mussel-inspired Agarose Hydrogel Scaffolds for Skin Tissue Engineering. Bioactive Materials 2020, 6 (3), 579-588.
  3. He, X., Zheng, Z., Zhang, F., Xu, C., Xu, W., Ye, L., Sun, X., Zhou, Z.*, Shen, J.*, Mitochondria-Targeted Chemosensor for Discriminately and Continuously Visualize HClO and H2S with Multi-Response Fluorescence Signals to Bioimaging in Vitro and in Vivo. ACS Applied Bio Materials 2020, https://doi.org/10.1021/acsabm.0c01029.
  4. He, X., Xu, W., Ding, F., Li, Y., Chen, H.*, Shen, J.*, A Reaction-Based Ratiometric and Colorimetric Chemosensor for Bioimaging of Biosulfite in Live Cells, Zebrafish and Food Samples. Journal of Agricultural and Food Chemistry. 2020, https://doi.org/10.1021/acs.jafc.0c03983.
  5. Liu, S.; Li, R.; Qian, J.; Sun, J.; Li, G.; Shen, J.; Xie, Y. Combination Therapy of Doxorubicin and Quercetin on Multidrug-Resistant Breast Cancer and Their Sequential Delivery by Reduction-Sensitive Hyaluronic Acid-Based Conjugate/d-α-Tocopheryl Poly(ethylene glycol) 1000 Succinate Mixed Micelles. Molecular Pharmaceutics 2020, 17, 1415-1427.
  6. Zhang, L., Mu, C., Zhang, T., Wang, Y., Wang, Y., Fan, L., Liu, C., Chen, H., Shen, J.*, Wei, K., Li, H. Systemic Delivery of Aptamer-Conjugated XBP1 siRNA Nanoparticles for Efficient Suppression of HER2+ Breast Cancer. ACS Applied Materials & Interfaces. 2020;12(29), 32360–32371.
  7. Qi, X., Zeng, Q., Tong, X., Su, T., Xie, L., Yuan, K., Xu, J., Shen, J.* Polydopamine/montmorillonite-embedded pullulan hydrogels as efficient adsorbents for removing crystal violet. Journal of Hazardous Materials. 2020;402, 123359.
  8. Chen H., Ding F., Zhou Z., He X., Shen, J.* FRET-based sensor for visualizing pH variation with colorimetric/ratiometric strategy and application for bioimaging in living cells, bacteria and zebrafish. Analyst. 2020;145(12):4283-4294.
  9. He, X., Deng Z., Xu W., Li Y., Xu C., Chen H., Shen, J.* A novel dual-response chemosensor for bioimaging of Exogenous/Endogenous hypochlorite and hydrazine in living cells, Pseudomonas aeruginosa and zebrafish. Sensors and Actuators B: Chemical, 2020. 321: p. 128450.
  10. Tong, X., X. Qi, R. Mao, W. Pan, M. Zhang, X. Wu, G. Chen, Shen, J.* H. Deng, and R. Hu, Construction of functional curdlan hydrogels with bio-inspired polydopamine for synergistic periodontal antibacterial therapeutics. Carbohydrate Polymers, 2020. 245: p. 116585.
  11. He, X., Xu W., Xu C., Ding F., Chen H., and Shen, J.* Reversible spiropyran-based chemosensor with pH-switches and application for bioimaging in living cells, Pseudomonas aeruginosa and zebrafish. Dyes and Pigments, 2020. 180: p. 108497.
  12. He, X., Ding F., Xu W., Xu C., Li Y., Qian Y., Zhao S., Chen H., and Shen, J.* FRET-based colorimetric and ratiometric sensor for visualizing pH change and application for bioimaging in living cells, bacteria and zebrafish. Analytica Chimica Acta, 2020. 1127: p. 29-38.
  13. Shen, L., Y. Li, Q. Lu, X. Qi, X. Wu, Shen, J.* Facile preparation of one-dimensional nanostructures through polymerization-induced self-assembly mediated by host–guest interaction. Polymer Chemistry, 2020. 11(26): p. 4208-4212.
  14. Zhao S, Yu X, Qian Y, Chen W, Shen, J.* Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics. Theranostics. 2020 May 15;10(14):6278-6309.
  15. Li Z, Xiong W, He X, Qi X, Ding F, Shen, J.* A novel strategy for rhodamine B-based fluorescent probes with a selective glutathione response for bioimaging in living cells. Analyst. 2020;145(12):4239-4244.
  16. Chen, H.; He, X.; Yu, Y.; Qian, Y.; Shen, J.;* Zhao, S.* Execution of aggregation-induced emission as nano-sensors for hypochlorite detection and application for bioimaging in living cells and zebrafish. Talanta 2020, 214, 120842.
  17. Chen, H.; Qian, Y.; Jia, H.; Yu, Y.; Zhang, H.; Zhao, S.; Shen, J.* Synthesis and pharmacological evaluation of naftopidil-based arylpiperazine derivatives containing the bromophenol moiety. Pharmacological Reports 2020.
  18. Chen, H.; Yang, P.; Li, Y.; Zhang, L.; Ding, F.; He, X.; Shen, J.* Insight into triphenylamine and coumarin serving as copper (II) sensors with “OFF” strategy and for bio-imaging in living cells. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2020, 224, 117384.
  19. He, X.; Chen, H.; Xu, C.; Fan, J.; Xu, W.; Li, Y.; Deng, H.; Shen, J.* Ratiometric and colorimetric fluorescent probe for hypochlorite monitor and application for bioimaging in living cells, bacteria and zebrafish. Journal of Hazardous Materials 2020, 388, 122029.
  20. He, X.; Xie, Q.; Fan, J.; Xu, C.; Xu, W.; Li, Y.; Ding, F.; Deng, H.; Chen, H.; Shen, J.* Dual-functional chemosensor with colorimetric/ratiometric response to Cu(II)/Zn(II) ions and its applications in bioimaging and molecular logic gates. Dyes and Pigments 2020, 177, 108255.
  21. He, X.; Xiong, W.; LileiZhang; Xu, C.; Fan, J.; Qian, Y.; Wen, J.; Ding, F.; Shen, J.* ESIPT-based ratiometric fluorescent probe for highly selective and sensitive sensing and bioimaging of group IIIA ions in living cancer cells and zebrafish. Dyes and Pigments 2020, 174, 108059.
  22. He, X.; Xu, C.; Xiong, W.; Qian, Y.; Fan, J.; Ding, F.; Deng, H.; Chen, H.; Shen, J.* The ICT-based fluorescence and colorimetric dual sensing of endogenous hypochlorite in living cells, bacteria, and zebrafish. Analyst 2020, 145, 29-33.
  23. Qi, X.; Su, T.; Zhang, M.; Tong, X.; Pan, W.; Zeng, Q.; Shen, J.* Sustainable, flexible and biocompatible hydrogels derived from microbial polysaccharides with tailorable structures for tissue engineering. Carbohydrate Polymers 2020, 237, 116160.
  24. Qi, X.; Su, T.; Zhang, M.; Tong, X.; Pan, W.; Zeng, Q.; Zhou, Z.; Shen, L.; He, X.; Shen, J.* Macroporous Hydrogel Scaffolds with Tunable Physicochemical Properties for Tissue Engineering Constructed Using Renewable Polysaccharides. ACS Applied Materials & Interfaces 2020. (Back Cover)
  25. Qi, X.; Zhang, M.; Su, T.; Pan, W.; Tong, X.; Zeng, Q.; Xiong, W.; Jiang, N.; Qian, Y.; Li, Z.; He, X.; Shen, L.; Zhou, Z.; Shen, J.* Biocompatible Hydrogels Based on Food Gums with Tunable Physicochemical Properties as Scaffolds for Cell Culture. Journal of Agricultural and Food Chemistry 2020.(Back Cover)
  26. Sang, Z.; Qian, J.; Han, J.; Deng, X.; Shen, J.; Li, G.; Xie, Y. Comparison of three water-soluble polyphosphate tripolyphosphate, phytic acid, and sodium hexametaphosphate as crosslinking agents in chitosan nanoparticle formulation. Carbohydrate Polymers 2020, 230, 115577.
  27. Shen, L.; Li, Y.; Lu, Q.; Qi, X.; Wu, X.; Zhou, Z.; Shen, J.* Directed arrangement of siRNA via polymerization-induced electrostatic self-assembly. Chemical Communications 2020, 56, 2411-2414.
  28. Zeng, Q.; Qi, X.; Zhang, M.; Tong, X.; Jiang, N.; Pan, W.; Xiong, W.; Li, Y.; Xu, J.; Shen, J.*, Xu, L.* Efficient decontamination of heavy metals from aqueous solution using pullulan/polydopamine hydrogels. International Journal of Biological Macromolecules 2020, 145, 1049-1058.
  29. Chen, H.; Yu, Y.-Z.; Tian, X.-M.; Wang, C.-L.; Qian, Y.-N.; Deng, Z.-A.; Zhang, J.-X.; Lv, D.-J.; Zhang, H.-B.; Shen, J.*.; Yuan, M.; Zhao, S.-C.* Synthesis and biological evaluation of arylpiperazine derivatives as potential anti-prostate cancer agents. Bioorganic & Medicinal Chemistry 2019, 27, 133-143.
  30. Chen, H.; Zhang, J.; Hu, P.; Qian, Y.; Li, J.; Shen, J.* Synthesis, biological evaluation and molecular docking of 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety. Bioorganic & Medicinal Chemistry 2019, 27, 115081.
  31. Fitzgerald, E. J.; Shen, J.; Fenniri, H. A Barcoded Polymer-Based Cross-Reactive Spectroscopic Sensor Array for Organic Volatiles. Sensors 2019, 19.
  32. Gao, J.; Chen, L.; Qi, R.; Zhou, Z.; Deng, Z.; Shi, J.; Qin, T.; Zhao, S.; Qian, Y.; Shen, J.* Simultaneous delivery of gene and chemotherapeutics via copolymeric micellar nanoparticles to overcome multiple drug resistance to promote synergistic tumor suppression. Journal of Biomaterials Applications 2019, 34, 130-140.
  33. He, X.; Wu, C.; Qian, Y.; Li, Y.; Ding, F.; Zhou, Z.; Shen, J.* Symmetrical bis-salophen probe serves as a selectively and sensitively fluorescent switch of gallium ions in living cells and zebrafish. Talanta 2019, 205, 120118.
  34. He, X.; Wu, C.; Qian, Y.; Li, Y.; Zhang, L.; Ding, F.; Chen, H.; Shen, J.* Highly sensitive and selective light-up fluorescent probe for monitoring gallium and chromium ions in vitro and in vivo. Analyst 2019, 144, 3807-3816.
  35. Huang, L.; Zhang, H.; Wu, S.; Xu, X.; Zhang, L.; Ji, H.; He, L.; Qian, Y.; Wang, Z.; Chen, Y.; Shen, J.*; Mao, Z.-W.*; Huang, Z*. Charge Regulation of Self-Assembled Tubules by Protonation for Efficiently Selective and Controlled Drug Delivery. IScience 2019, 19, 224-231.
  36. Liu, M.; Sun, X.; Liao, Z.; Li, Y.; Qi, X.; Qian, Y.; Fenniri, H.; Zhao, P.; Shen, J.* Zinc oxide end-capped Fe3O4@mSiO2 core-shell nanocarriers as targeted and responsive drug delivery system for chemo-/ions synergistic therapeutics. Drug Delivery 2019, 26, 732-743.
  37. Qi, X.; Chen, M.; Qian, Y.; Liu, M.; Li, Z.; Shen, L.; Qin, T.; Zhao, S.; Zeng, Q.; Shen, J.* Construction of macroporous salecan polysaccharide-based adsorbents for wastewater remediation. International Journal of Biological Macromolecules 2019, 132, 429-438.
  38. Qi, X.; Li, Z.; Shen, L.; Qin, T.; Qian, Y.; Zhao, S.; Liu, M.; Zeng, Q.; Shen, J.* Highly efficient dye decontamination via microbial salecan polysaccharide-based gels. Carbohydrate Polymers 2019, 219, 1-11.
  39. Qi, X.; Lin, L.; Shen, L.; Li, Z.; Qin, T.; Qian, Y.; Wu, X.; Wei, X.; Gong, Q.; Shen, J.* Efficient Decontamination of Lead Ions from Wastewater by Salecan Polysaccharide-Based Hydrogels. ACS Sustainable Chemistry & Engineering 2019, 7, 11014-11023.
  40. Qi, X.; Liu, R.; Chen, M.; Li, Z.; Qin, T.; Qian, Y.; Zhao, S.; Liu, M.; Zeng, Q.; Shen, J.* Removal of copper ions from water using polysaccharide-constructed hydrogels. Carbohydrate Polymers 2019, 209, 101-110. (ESI 1%)
  41. Qi, X.; Su, T.; Tong, X.; Xiong, W.; Zeng, Q.; Qian, Y.; Zhou, Z.; Wu, X.; Li, Z.; Shen, L.; He, X.; Xu, C.; Chen, M.; Li, Y.; Shen, J.* Facile formation of salecan/agarose hydrogels with tunable structural properties for cell culture. Carbohydrate Polymers 2019, 224, 115208.
  42. Qi, X.; Wei, W.; Shen, J.*; Dong, W. Salecan polysaccharide-based hydrogels and their applications: a review. Journal of Materials Chemistry B 2019, 7, 2577-2587.
  43. Qian, Y.; Zhao, S.; Shen, H.; Shen, J.* NanotechnologyAdvances in Medicine:Focus on Cancer. Engineered Science 2019.
  44. Sun, X.-Y.; Liu, M.-C.; Chen, X.-L.; Lin, H.-C.; Liu, B.; Peng, Y.-B.; Zhang, L.-Y.; Shen, J.*; Zhao, P. A dual-targeted nucleic acid moiety decorated SPION nanoparticles for chemo-photodynamic synergistic therapy. Journal of Luminescence 2019, 209, 387-397.
  45. Yang, Z.; Sun, Z.; Ren Yi; Xin, C.; Wei, Z.; Zhu, X.; Zongwan, M.; Shen, J.; Nie, S. Advances in nanomaterials for use in photothermal and photodynamic therapeutics Molecular Medicine Reports 2019, 5-20.
  46. Zhang, J.; Mai, J.; Li, F.; Shen, J.; Zhang, G.; Li, J.; Hinkle, L. E.; Lin, D.; Liu, X.; Li, Z.; Wang, R.-f.; Mittendorf, E. A.; Ferrari, M.; Shen, H. Investigation of parameters that determine Nano-DC vaccine transport. Biomedical Microdevices 2019, 21, 39.
  47. Ding, F.; Qian, Y.; Deng, Z.; Zhang, J.; Zhou, Y.; Yang, L.; Wang, F.; Wang, J.; Zhou, Z.; Shen, J.*. Size-selected silver nanoparticles for MALDI-TOF mass spectrometry of amyloid-beta peptides. Nanoscale 2018, 10, 22044-22054. (2018 Nanoscale HOT Article Collections)
  48. Liu, H.; Mai, J.; Shen, J.; Wolfram, J.; Li, Z.; Zhang, G.; Xu, R.; Li, Y.; Mu, C.; Zu, Y.; Li, X.; Lokesh, G. L.; Thiviyanathan, V.; Volk, D. E.; Gorenstein, D. G.; Ferrari, M.; Hu, Z.; Shen, H. A Novel DNA Aptamer for Dual Targeting of Polymorphonuclear Myeloid-derived Suppressor Cells and Tumor Cells. Theranostics 2018, 8, 31-44.
  49. Mu, C.; Wu, X.; Zhou, X.; Wolfram, J.; Shen, J.; Zhang, D.; Mai, J.; Xia, X.; Holder, A. M.; Ferrari, M.; Liu, X.; Shen, H. Chemotherapy sensitizes therapy-resistant cells to mild hyperthermia by suppressing heat shock protein 27 expression in triple negative breast cancer. Clinical Cancer Research 2018, clincanres.3872.2017. (Top Story in Mamarry Cell News)
  50. Mu, C.-F.; Shen, J.; Liang, J.; Zheng, H.-S.; Xiong, Y.; Wei, Y.-H.; Li, F. Targeted drug delivery for tumor therapy inside the bone marrow. Biomaterials 2018, 155, 191-202.
  51. Shen, J.; Zhang, W.; Qi, R.; Mao, Z.-W.; Shen, H. Engineering functional inorganic-organic hybrid systems: advances in siRNA therapeutics. Chem Soc Rev 2018, 47, 1969-1995. (Front Cover)
  52. Sun, J. H.; Zhang, W.; Zhang, D.-Y.; Shen, J.; Tan, C.-P.; Ji, L.-N.; Mao, Z.-W. Multifunctional mesoporous silica nanoparticles as efficient transporters of doxorubicin and chlorin e6 for chemo-photodynamic combinatorial cancer therapy. Journal of Biomaterials Applications 2018, 32, 1253-1264.
  53. Wang, F.; Xia, X.; Yang, C.; Shen, J.; Mai, J.; Kim, H.-C.; Kirui, D.; Kang, Y.; an; Fleming, J. B.; Koay, E. J.; Mitra, S.; Ferrari, M.; Shen, H. SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy. Clinical Cancer Research 2018, 24, 3176.
  54. Deng, B.; Xia, M.; Qian, J.; Li, R.; Li, L.; Shen, J.; Li, G.; Xie, Y. Calcium Phosphate-Reinforced Reduction-Sensitive Hyaluronic Acid Micelles for Delivering Paclitaxel in Cancer Therapy. Molecular Pharmaceutics 2017, 14, 1938-1949.
  55. Shen, J.; Kim, H.-C.; Wolfram, J.; Mu, C.; Zhang, W.; Liu, H.; Xie, Y.; Mai, J.; Zhang, H.; Li, Z.; Guevara, M.; Mao, Z.-W.; Shen, H. A Liposome Encapsulated Ruthenium Polypyridine Complex as a Theranostic Platform for Triple-Negative Breast Cancer. Nano Letters 2017, 17, 2913-2920. (Top Story in Mamarry Cell News)
  56. Shen, J.; Liu, H.; Mu, C.; Wolfram, J.; Zhang, W.; Kim, H.-C.; Zhu, G.; Hu, Z.; Ji, L.-N.; Liu, X.; Ferrari, M.; Mao, Z.-W.; Shen, H. Multi-step encapsulation of chemotherapy and gene silencing agents in functionalized mesoporous silica nanoparticles. Nanoscale 2017, 9, 5329-5341.
  57. Shen, J.; Wolfram, J.; Ferrari, M.; Shen, H. Taking the vehicle out of drug delivery. Mater Today (Kidlington) 2017, 20, 95-97.
  58. Mu, C.; Wu, X.; Ma, H.; Tao, W.; Zhang, G.; Xia, X.; Shen, J.; Mai, J.; Sun, T.; Sun, X.; Arlinghaus, R. B.; Shen, H. Effective Concentration of a Multikinase Inhibitor within Bone Marrow Correlates with In Vitro Cell Killing in Therapy-Resistant Chronic Myeloid Leukemia. Mol Cancer Ther 2016, 15, 899-910.
  59. Scott, B.; Shen, J.; Nizzero, S.; Boom, K.; Persano, S.; Mi, Y.; Liu, X.; Zhao, Y.; Blanco, E.; Shen, H.; Ferrari, M.; Wolfram, J. A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells. Pharmacological Research 2016, 111, 413-421.
  60. Wolfram, J.; Scott, B.; Boom, K.; Shen, J.; Borsoi, C.; Suri, K.; Grande, R.; Fresta, M.; Celia, C.; Zhao, Y.; Shen, H.; Ferrari, M. Hesperetin Liposomes for Cancer Therapy. Curr Drug Deliv 2016, 13, 711-719.
  61. Xu, R.; Zhang, G.; Mai, J.; Deng, X.; Segura-Ibarra, V.; Wu, S.;         Shen, J.; Liu, H.; Hu, Z.; Chen, L.; Huang, Y.; Koay, E.; Huang, Y.; Liu, J.; Ensor, J. E.; Blanco, E.; Liu, X.; Ferrari, M.; Shen, H. An injectable nanoparticle generator enhances delivery of cancer therapeutics. Nature Biotechnology 2016, 34, 414-418. (Hot Paper, ESI 1%)
  62. Zhang, W.; Shen, J.; Su, H.; Mu, G.; Sun, J.-H.; Tan, C.-P.; Liang, X.-J.; Ji, L.-N.; Mao, Z.-W. Co-Delivery of Cisplatin Prodrug and Chlorin e6 by Mesoporous Silica Nanoparticles for Chemo-Photodynamic Combination Therapy to Combat Drug Resistance. ACS Applied Materials & Interfaces 2016, 8, 13332-13340.
  63. Shen, J.; Wu, X.; Lee, Y.; Wolfram, J.; Yang, Z.; Mao, Z.-W.; Ferrari, M.; Shen, H. Porous Silicon Microparticles for Delivery of siRNA Therapeutics. JoVE 2015, e52075.
  64. Wolfram, J.; Zhu, M.; Yang, Y.; Shen, J.; Gentile, E.; Paolino, D.; Fresta, M.; Nie, G.; Chen, C.; Shen, H.; Ferrari, M.; Zhao, Y. Safety of Nanoparticles in Medicine. Current Drug Targets 2015, 16, 1671-1681.
  65. Shen, J.; Kim, H.-C.; Mu, C.; Gentile, E.; Mai, J.; Wolfram, J.; Ji, L.-n.; Ferrari, M.; Mao, Z.-w.; Shen, H. Multifunctional Gold Nanorods for siRNA Gene Silencing and Photothermal Therapy. Advanced Healthcare Materials 2014, 3, 1629-1637.
  66. Shen, J.; Kim, H.-C.; Su, H.; Wang, F.; Wolfram, J.; Kirui, D.; Mai, J.; Mu, C.; Ji, L.-N.; Mao, Z.-W.; Shen, H. Cyclodextrin and polyethylenimine functionalized mesoporous silica nanoparticles for delivery of siRNA cancer therapeutics. Theranostics 2014, 4, 487-497. (ESI 1%)
  67. Wolfram, J.; Suri, K.; Yang, Y.; Shen, J.; Celia, C.; Fresta, M.; Zhao, Y.; Shen, H.; Ferrari, M. Shrinkage of pegylated and non-pegylated liposomes in serum. Colloids and Surfaces B: Biointerfaces 2014, 114, 294-300.
  68. Wolfram, J.; Yang, Y.; Shen, J.; Moten, A.; Chen, C.; Shen, H.; Ferrari, M.; Zhao, Y. The nano-plasma interface: Implications of the protein corona. Colloids and Surfaces B: Biointerfaces 2014, 124, 17-24.
  69. Shen, J.; Xu, R.; Mai, J.; Kim, H.-C.; Guo, X.; Qin, G.; Yang, Y.; Wolfram, J.; Mu, C.; Xia, X.; Gu, J.; Liu, X.; Mao, Z.-W.; Ferrari, M.; Shen, H. High capacity nanoporous silicon carrier for systemic delivery of gene silencing therapeutics. ACS nano 2013, 7, 9867-9880. (ESI 1%)
  70. Yang, Y.; Shen, J.; Yu, X.; Qin, G.; Zhang, M.; Shen, H.; Mao, Z.; Ferrari, M. Identification of an inhibitory mechanism of luteolin on the insulin-like growth factor-1 ligand-receptor interaction. Chembiochem 2013, 14, 929-933.
  71. Yang, Y.; Wolfram, J.; Shen, J.; Zhao, Y.; Fang, X.; Shen, H.; Ferrari, M. Live-cell single-molecule imaging reveals clathrin and caveolin-1 dependent docking of SMAD4 at the cell membrane. FEBS Lett 2013, 587, 3912-3920.
  72. Tan, L.; Shen, J.; Liu, J.; Zeng, L.; Jin, L.; Weng, C. Spectral characteristics, DNA-binding and cytotoxicity of two functional Ru(ii) mixed-ligand complexes. Dalton Transactions 2012, 41, 4575-4587.
  73. Tan, L.-F.; Chen, X.-J.; Shen, J.; Liang, X.-L. Synthesis, DNA-binding and photocleavage studies of Ru(II) complexes of phenyl-(4,5,9,14-tetraaza-benzo[b]triphenylen-1,1-yl)-methanone. Journal of Chemical Sciences 2009, 121, 397-405.
  74. Tan, L.-F.; Liu, J.; Shen, J.; Liu, X.-h.; Zeng, L.-L.; Jin, L.-H. First Ruthenium(II) Polypyridyl Complex As a True Molecular “Light Switch” for Triplex RNA Structure: [Ru(phen)2(mdpz)]2+ Enhances the Stability of Poly(U)·Poly(A)*Poly(U). Inorganic Chemistry 2012, 51, 4417-4419.
  75. Tan, L.-F.; Shen, J.; Chen, X.-J.; Liang, X.-L. In vitro study on DNA binding of ruthenium(II) complexes with polypyridyl ligands. DNA and Cell Biology 2012, 28, 461-468.

Grant Project as Principal Investigator (PI) or Co-PI

  1. The National Natural Science Foundation of China, 21977081, Studies on Tumor Microenvironment-multitargeted Delivery Vehicle for Therapeutic siRNA and Treatment for Triple Negative Breast Cancer. 2020.1-2023.12, ¥660000.
  2. Major Cultivation Project of Wenzhou Medical University, TQJ17026, Micro-Environment Responsive Nanomaterials for siRNA Therapeutics. 2020.1-2023.12, ¥500000.
  3. Sub-Topic of High-throughput Screening of New Coronary Pneumonia Drugs Based on Bionic Lung Chips, WIUCASYJ2020001-2, 2020.1-2020.12, ¥300000.
  4. “Qianjiang” Talent Project of Zhejiang Province, Tumor Microenvironment-multitargeted Vehicle for Therapeutic siRNA, 2020.1-2022.12, ¥50000.
  5. Key Project of Zhejiang Natural Science Foundation, Studies on Tumor Microenvironment-multitargeted Delivery Vehicle for Therapeutic siRNA, LZ19H180001, 2019.1-2022.12, ¥350000.
  6. The National Natural Science Foundation of China, 31800833, Studies on Fabrication and Activity of Self-assembled Nanoparticle between Multi-nuclear Platin compound and siRNA, 2019.1-2021.12, ¥270000.
  7. Wenzhou Basic Scientific Research Project, Y20190054,2020.1-2021.6, ¥30000.
  8. Wenzhou Basic Scientific Research Project, Y20180071,2018.1-2020.12, ¥30000.
  9. Wenzhou City Industry-University-Research Innovation Project, 2019.1-2020.12, ¥20000.
  10. Key Project of Wenzhou Institute of Biomaterials & Engineering, WIBEZD2017001-03, Tumor-Microenvironment Responsive Nanomaterials for siRNA Therapeutics, 2017.9-2022.8, ¥1500000.
  11. Start-up Founding of Wenzhou Medical University, WMU2018017-23. Theranostic Nanomaterials for Cancer Therapeutics. 2018.5-2023.5, ¥1500000.
  12. Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, No. CQKLBST-2018-005, 2018.6-2020.6, ¥50000.
  13. The National Natural Science Foundation of China, 20231007, Construction of cyclodextrin functionalized inorganic nanomaterials and its targeting therapeutics、2013.1-2017.12, ¥3200000.
  14. The National Natural Science Foundation of China, 21272285, Synthesis and catalytic properties of multi tooth NHC-Cabin high valent transition metal complexes ,2013.1-2016.12, ¥800000.
  15. The National Institute of Health (RO1), 1R01CA193880-01A1, Tumor Vasculature-targeted Nanotherapeutics for DNA Damage Response, 2015.12-2020.11, $1824280.
  16. Department of Defense, U54CA151668, Multistage vector-enabled breast oncology, 2012.9-2017.9, $3110000.
  17. Nationals Cancer Institute (U54), U54CA143837, Texas Center for Cancer Nanomedicine, 2010.9-2015.8, $12120815.

Professional Societies

  1. Editor-in-Chief of Advanced Applied Materials,
  2. Honor Editor of Journal of American Nanotechnology and Nanomedicine,
  3. Yong Editorial Committee of Chinese Chemical Letters,
  4. Guest Editor of Frontiers in Chemistry,
  5. Guest Editor of Biosensors;
  6. Reviewer of Nature Sustainability, Journal of Cheminformatics, Theranostics. Nanoscale, Angewandte International Edition Chemie, Coordination Chemistry Reviews, ACS Nano and other 20 journals.

Important Academic Awards

  1. Fulan doctoral scholarship, Guangzhou, China, 2010.
  2. Research Merit Award, Houston, USA, 2014
  3. Fulan doctoral scholarship, Guangzhou, China, 2014.
  4. MAPTA Travelling Award, Houston, USA, 2017
  5. Youth Top Talent Project of Wenzhou City, China, 2019
  6. Youth Top Talent Project of Hunan Province, China, 2019
  7. Outstanding Young Talents of Zhejiang Universities, 2020
  8. “Qianjiang” Talent Project of Zhejiang Province, China, 2020

Applied and Acquired Patents

  1. Shen H., Ferrari M., Shen J., Zhang M., US20160369269A1, Polycation-functionalized nanoporous silicon carrier for systemic delivery of gene silencing agents.
  2. He X.J., Shen J., 2019111262091, Preparation method and application of aggregation-induced emission based small molecule fluorescent probe.
  3. Shen J., He X.J., 201910808566X, Preparation method and application of small molecule fluorescent probe using 3-hydroxyflavonoid as fluorophore.
  4. He X.J., Shen J., 2019108137490, Preparation method and application of small molecule fluorescent probe.
  5. Shen J., He X.J., 2019104591639, Preparation method and application of small molecule fluorescent probe using CS as fluorophore.
  6. Shen J., He X.J., 2019104580920, Preparation method and application of small molecule fluorescent probe using TS as fluorophore.
  7. He X.J., Shen J., 2019101114498, Preparation method and application of small molecule probe H4L.
  8. He X.J., Shen J., 2019101114500, Preparation method and application of small molecule probe.
  9. Shen J., Qian Y.N., 2018105667490, Platinum-derived drug self-delivery gene drug carrier and use method.
  10. Shen J., Zhao P., Liu M.C., Qian Y.N., 2018107012544, Multifunctional core-shell structure Fe3O4 @ TiO2 @ ZIF-8 nanoparticle drug-loading system and preparation method.
  11. Shen J., Qian Y.N., 201810540268.2, A Liposome encapsulated ruthenium polypyridine complex and its application.
  12. Shen J., Chen H., Qian Y.N., 2018107180145, Chinese medicine formula for treating oral ulcer and preparation method.
  13. Shen J., Chen H., Qian Y.N., 2018107169235, Chewing gum lozenge for treating oral ulcer and preparation method.
  14. Shen J., Qian Y.N., 201810535739, A kind of cyclodextrin mesoporous silicon nanoparticles.
  15. Shen J., Qian Y.N., 2018105662637, Gene medicine carrier with multistage response of tumor microenvironment and using method.

Important Position in International Academic Conferences

  1. Abstract at the 11th national conference on biological inorganic chemistry. Multi-nuclear Ru Compounds interaction with G-quadruplex. Baoding, Hebei, China, 2011.
  2. Abstract at the 12th international symposium on applied bioinorganic  chemistry, High Capacity Nanoporous Silicon Carrier for Systemic Delivery of Gene Silencing Therapeutics. Guangzhou, China, 2013.
  3. Oral presentation at 2014 MAPTA Traveling Award， Mesoporous Silica Nanoparticles for siRNA Delivery, Houston, USA, 2014.
  4. Abstract at the 3rd Annual MAPTA Winter Science Symposium 2016, Multi-stage Vectors for SIrna Therapeutics. Houston, USA, 2016.
  5. Oral presentation at 2017 Nanhu academic Forum (Forum on the Frontier and Development Strategy of Bioinorganic Chemistry Research), Taking the Vehicle Out of Drug Delivery: Green Nanotherapeutics, Jiaxing, China, 2017
  6. Invitation presentation at Chemistry College of Xiangtan University, Engineering Functional Inorganic-Organic Hybrid System Advances in siRNA Therapeutics, Xiangtan, China, 2017.
  7. Invitation presentation at Hunan University of Science and Technology, Engineering Functional Inorganic-Organic Hybrid System Advances in siRNA Therapeutics. Xiangtan, China, 2017.
  8. Invitation presentation at Hunan University of Technology, Theranostic Inorganic-Organic Hybrid System Advances in Cancer Therapeutics. Zhuzhou, China, 2018.
  9. Invitation presentation at Luoyang Normal University, Theranostic Inorganic-Organic Hybrid System Advances in Drug Delivery. Luoyang, China, 2018.
  10. Oral presentation at 2018 Central-West Conference on bioinorganic chemistry, Engineering Functional Inorganic-Organic Hybrid System Advances in siRNA Therapeutics. Wuhan, China, 2018.
  11. Invitation presentation at Zhezhou University, Theranostic Inorganic-Organic Hybrid System Advances in Drug Delivery. Luoyang, China, 2018.
  12. Invitation presentation at Zhoukou Normal University, Theranostic Inorganic-Organic Hybrid System Advances in Drug Delivery. Luoyang, China, 2018.
  13. Oral presentation at China 31st annual meeting of bioinorganic chemistry，Engineering Functional Inorganic-Organic Hybrid System Advances in siRNA Therapeutics. Hangzhou, China, 2018.
  14. Oral presentation at China 11st annual meeting of bioinorganic chemistry，Engineering Functional Inorganic-Organic Hybrid System Advances in siRNA Therapeutics. Hangzhou, China, 2019.
  15. Invitation presentation at Shanghai Jiao Tong University, Engineering Functional Inorganic-Organic Hybrid System Advances in siRNA Therapeutics. Shanghai, China, 2019.
  16. Invitation presentation at China Three Gores University, Engineering Functional Inorganic-Organic Hybrid System Advances in siRNA Therapeutics. Guangzhou, China, 2019.
  17. Invitation presentation at Kunming University of Science and Technology, Engineering Functional Inorganic-Organic Hybrid System Advances in siRNA Therapeutics. Guangzhou, China, 2019.
  18. Invitation presentation at Shanghai University of Traditional Chinese Medicine, Engineering Functional Inorganic-Organic Hybrid System Advances in siRNA Therapeutics. Guangzhou, China, 2019.
  19. Invitation presentation at Tianshui Normal University, Engineering Functional Inorganic-Organic Hybrid System Advances in siRNA Therapeutics. Guangzhou, China, 2019.
  20. Invitation presentation 2019 Chinese Conference on Oncology- Nano-Oncology Committee Sub-Forum, Engineering Functional Inorganic-Organic Hybrid System Advances in siRNA Therapeutics. Guangzhou, China, 2019.

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