1. 2012年6月－2014年6月：博士研究生、康奈尔医学院休斯顿卫理公会研究所，沈海法教授
2. 2010年9月－2014年6月：博士研究生、无机化学，中山大学，毛宗万教授
3. 2007年9月－2010年6月：硕士研究生、无机化学，湘潭大学，谭黎峰教授
4. 2003年9月－2007年6月：学士、应用化学，湖南科技大学， 周智华教授

1. 2017年10月－至今：研究员、中国科学院大学温州研究院
2. 2017年10月－至今：研究员、温州医科大学眼视光学院 (生物医学工程学院)、眼视光附属医院
3. 2014年6月－2017 年6月：博士后、康奈尔医学院休斯顿卫理公会研究所，沈海法教授
4. 2012年6月－2014 年6月：助理研究员、康奈尔医学院休斯顿卫理公会研究所，沈海法教授

1. 智能化纳米材料递送基因药物
2. 药物自组装的自我递送
3. 肿瘤微环境响应的多级靶向递送体系
4. 功能化水凝胶的生物医药应用
5. 纳米免疫治疗

研究主要集中于纳米材料、纳米技术等在生物医学领域中的探究，主要应用于癌症的成像和治疗、眼科以及其他疾病的诊疗一体化应用。利用纳米材料技术和多学科的交叉优势解决癌症和其他疾病医疗诊断等领域所面临的挑战和瓶颈。已申报授权专利23项，其中美国专利授权1项。在国际权威学术期刊已发表70多篇相关学术论文，5篇 ESI 1%论文。研究工作以第一/通讯作者发表在ACS Nano, Nano Letters, Materials Today, Chemical Society Reviews和IScience等专业领域主流期刊上，被引达1770余次。并受邀国内会议邀请报告和口头报考20余次。目前主持国家自然科学基金面上和青年项目、浙江省自然科学基金重点项目、温州研究院重点专项和温州市创新自然基金等10余个科研项目。相继荣获了芙兰奖 (2010和2014年)、Research Merit Award (National Cancer Institute U54 Center for Cancer Nanotechnology Excellence Grant Program)、MAPTA Travel Award (Houston Methodist Research Institute)、湖湘青年英才、浙江省高校青年优秀人才、浙江省钱江人才、温州市青年拔尖人才等国内外奖项和荣誉。

1. Zhang M., Huang Y., Pan X., Tong X., Zeng Q., Su T., Qi X., Shen, J.^*, Polydopamine-incorporated dextran hydrogel drug carrier with tailorable structure for wound healing, Carbohydrate Polymers, 2020, 117213.
2. Su, T., Zhang, M., Pan, W., Qian, Y., Zhou, Z., He, X., Shen, L., Dong, W., Qi, X.^*, Shen, J.^*, Mussel-inspired Agarose Hydrogel Scaffolds for Skin Tissue Engineering. Bioactive Materials 2020, 6 (3), 579-588.
3. He, X., Zheng, Z., Zhang, F., Xu, C., Xu, W., Ye, L., Sun, X., Zhou, Z.^*, Shen, J.^*, Mitochondria-Targeted Chemosensor for Discriminately and Continuously Visualize HClO and H2S with Multi-Response Fluorescence Signals to Bioimaging in Vitro and in Vivo. ACS Applied Bio Materials 2020, https://doi.org/10.1021/acsabm.0c01029.
4. He, X., Xu, W., Ding, F., Li, Y., Chen, H.^*, Shen, J.^*, A Reaction-Based Ratiometric and Colorimetric Chemosensor for Bioimaging of Biosulfite in Live Cells, Zebrafish and Food Samples. Journal of Agricultural and Food Chemistry. 2020, https://doi.org/10.1021/acs.jafc.0c03983.
5. Liu, S.; Li, R.; Qian, J.; Sun, J.; Li, G.; Shen, J.; Xie, Y. Combination Therapy of Doxorubicin and Quercetin on Multidrug-Resistant Breast Cancer and Their Sequential Delivery by Reduction-Sensitive Hyaluronic Acid-Based Conjugate/d-α-Tocopheryl Poly(ethylene glycol) 1000 Succinate Mixed Micelles. Molecular Pharmaceutics 2020, 17, 1415-1427.
6. Zhang, L., Mu, C., Zhang, T., Wang, Y., Wang, Y., Fan, L., Liu, C., Chen, H., Shen, J.^*, Wei, K., Li, H. Systemic Delivery of Aptamer-Conjugated XBP1 siRNA Nanoparticles for Efficient Suppression of HER2+ Breast Cancer. ACS Applied Materials & Interfaces. 2020;12(29), 32360–32371.
7. Qi, X., Zeng, Q., Tong, X., Su, T., Xie, L., Yuan, K., Xu, J., Shen, J.^* Polydopamine/montmorillonite-embedded pullulan hydrogels as efficient adsorbents for removing crystal violet. Journal of Hazardous Materials. 2020;402, 123359.
8. Chen H., Ding F., Zhou Z., He X., Shen, J.^* FRET-based sensor for visualizing pH variation with colorimetric/ratiometric strategy and application for bioimaging in living cells, bacteria and zebrafish. Analyst. 2020;145(12):4283-4294.
9. He, X., Deng Z., Xu W., Li Y., Xu C., Chen H., Shen, J.^* A novel dual-response chemosensor for bioimaging of Exogenous/Endogenous hypochlorite and hydrazine in living cells, Pseudomonas aeruginosa and zebrafish. Sensors and Actuators B: Chemical, 2020. 321: p. 128450.
10. Tong, X., X. Qi, R. Mao, W. Pan, M. Zhang, X. Wu, G. Chen, Shen, J.^* H. Deng, and R. Hu, Construction of functional curdlan hydrogels with bio-inspired polydopamine for synergistic periodontal antibacterial therapeutics. Carbohydrate Polymers, 2020. 245: p. 116585.
11. He, X., Xu W., Xu C., Ding F., Chen H., and Shen, J.^* Reversible spiropyran-based chemosensor with pH-switches and application for bioimaging in living cells, Pseudomonas aeruginosa and zebrafish. Dyes and Pigments, 2020. 180: p. 108497.
12. He, X., Ding F., Xu W., Xu C., Li Y., Qian Y., Zhao S., Chen H., and Shen, J.^* FRET-based colorimetric and ratiometric sensor for visualizing pH change and application for bioimaging in living cells, bacteria and zebrafish. Analytica Chimica Acta, 2020. 1127: p. 29-38.
13. Shen, L., Y. Li, Q. Lu, X. Qi, X. Wu, Shen, J.^* Facile preparation of one-dimensional nanostructures through polymerization-induced self-assembly mediated by host–guest interaction. Polymer Chemistry, 2020. 11(26): p. 4208-4212.
14. Zhao S, Yu X, Qian Y, Chen W, Shen, J.^* Multifunctional magnetic iron oxide nanoparticles: an advanced platform for cancer theranostics. Theranostics. 2020 May 15;10(14):6278-6309.
15. Li Z, Xiong W, He X, Qi X, Ding F, Shen, J.^* A novel strategy for rhodamine B-based fluorescent probes with a selective glutathione response for bioimaging in living cells. Analyst. 2020;145(12):4239-4244.
16. Chen, H.; He, X.; Yu, Y.; Qian, Y.; Shen, J.;^* Zhao, S.^* Execution of aggregation-induced emission as nano-sensors for hypochlorite detection and application for bioimaging in living cells and zebrafish. Talanta 2020, 214, 120842.
17. Chen, H.; Qian, Y.; Jia, H.; Yu, Y.; Zhang, H.; Zhao, S.; Shen, J.^* Synthesis and pharmacological evaluation of naftopidil-based arylpiperazine derivatives containing the bromophenol moiety. Pharmacological Reports 2020.
18. Chen, H.; Yang, P.; Li, Y.; Zhang, L.; Ding, F.; He, X.; Shen, J.^* Insight into triphenylamine and coumarin serving as copper (II) sensors with “OFF” strategy and for bio-imaging in living cells. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2020, 224, 117384.
19. He, X.; Chen, H.; Xu, C.; Fan, J.; Xu, W.; Li, Y.; Deng, H.; Shen, J.^* Ratiometric and colorimetric fluorescent probe for hypochlorite monitor and application for bioimaging in living cells, bacteria and zebrafish. Journal of Hazardous Materials 2020, 388, 122029.
20. He, X.; Xie, Q.; Fan, J.; Xu, C.; Xu, W.; Li, Y.; Ding, F.; Deng, H.; Chen, H.; Shen, J.^* Dual-functional chemosensor with colorimetric/ratiometric response to Cu(II)/Zn(II) ions and its applications in bioimaging and molecular logic gates. Dyes and Pigments 2020, 177, 108255.
21. He, X.; Xiong, W.; LileiZhang; Xu, C.; Fan, J.; Qian, Y.; Wen, J.; Ding, F.; Shen, J.^* ESIPT-based ratiometric fluorescent probe for highly selective and sensitive sensing and bioimaging of group IIIA ions in living cancer cells and zebrafish. Dyes and Pigments 2020, 174, 108059.
22. He, X.; Xu, C.; Xiong, W.; Qian, Y.; Fan, J.; Ding, F.; Deng, H.; Chen, H.; Shen, J.^* The ICT-based fluorescence and colorimetric dual sensing of endogenous hypochlorite in living cells, bacteria, and zebrafish. Analyst 2020, 145, 29-33.
23. Qi, X.; Su, T.; Zhang, M.; Tong, X.; Pan, W.; Zeng, Q.; Shen, J.^* Sustainable, flexible and biocompatible hydrogels derived from microbial polysaccharides with tailorable structures for tissue engineering. Carbohydrate Polymers 2020, 237, 116160.
24. Qi, X.; Su, T.; Zhang, M.; Tong, X.; Pan, W.; Zeng, Q.; Zhou, Z.; Shen, L.; He, X.; Shen, J.^* Macroporous Hydrogel Scaffolds with Tunable Physicochemical Properties for Tissue Engineering Constructed Using Renewable Polysaccharides. ACS Applied Materials & Interfaces 2020. (Back Cover)
25. Qi, X.; Zhang, M.; Su, T.; Pan, W.; Tong, X.; Zeng, Q.; Xiong, W.; Jiang, N.; Qian, Y.; Li, Z.; He, X.; Shen, L.; Zhou, Z.; Shen, J.^* Biocompatible Hydrogels Based on Food Gums with Tunable Physicochemical Properties as Scaffolds for Cell Culture. Journal of Agricultural and Food Chemistry 2020.(Back Cover)
26. Sang, Z.; Qian, J.; Han, J.; Deng, X.; Shen, J.; Li, G.; Xie, Y. Comparison of three water-soluble polyphosphate tripolyphosphate, phytic acid, and sodium hexametaphosphate as crosslinking agents in chitosan nanoparticle formulation. Carbohydrate Polymers 2020, 230, 115577.
27. Shen, L.; Li, Y.; Lu, Q.; Qi, X.; Wu, X.; Zhou, Z.; Shen, J.^* Directed arrangement of siRNA via polymerization-induced electrostatic self-assembly. Chemical Communications 2020, 56, 2411-2414.
28. Zeng, Q.; Qi, X.; Zhang, M.; Tong, X.; Jiang, N.; Pan, W.; Xiong, W.; Li, Y.; Xu, J.; Shen, J.^*, Xu, L.^* Efficient decontamination of heavy metals from aqueous solution using pullulan/polydopamine hydrogels. International Journal of Biological Macromolecules 2020, 145, 1049-1058.
29. Chen, H.; Yu, Y.-Z.; Tian, X.-M.; Wang, C.-L.; Qian, Y.-N.; Deng, Z.-A.; Zhang, J.-X.; Lv, D.-J.; Zhang, H.-B.; Shen, J.^*.; Yuan, M.; Zhao, S.-C.^* Synthesis and biological evaluation of arylpiperazine derivatives as potential anti-prostate cancer agents. Bioorganic & Medicinal Chemistry 2019, 27, 133-143.
30. Chen, H.; Zhang, J.; Hu, P.; Qian, Y.; Li, J.; Shen, J.^* Synthesis, biological evaluation and molecular docking of 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs containing the piperazine moiety. Bioorganic & Medicinal Chemistry 2019, 27, 115081.
31. Fitzgerald, E. J.; Shen, J.; Fenniri, H. A Barcoded Polymer-Based Cross-Reactive Spectroscopic Sensor Array for Organic Volatiles. Sensors 2019, 19.
32. Gao, J.; Chen, L.; Qi, R.; Zhou, Z.; Deng, Z.; Shi, J.; Qin, T.; Zhao, S.; Qian, Y.; Shen, J.^* Simultaneous delivery of gene and chemotherapeutics via copolymeric micellar nanoparticles to overcome multiple drug resistance to promote synergistic tumor suppression. Journal of Biomaterials Applications 2019, 34, 130-140.
33. He, X.; Wu, C.; Qian, Y.; Li, Y.; Ding, F.; Zhou, Z.; Shen, J.^* Symmetrical bis-salophen probe serves as a selectively and sensitively fluorescent switch of gallium ions in living cells and zebrafish. Talanta 2019, 205, 120118.
34. He, X.; Wu, C.; Qian, Y.; Li, Y.; Zhang, L.; Ding, F.; Chen, H.; Shen, J.^* Highly sensitive and selective light-up fluorescent probe for monitoring gallium and chromium ions in vitro and in vivo. Analyst 2019, 144, 3807-3816.
35. Huang, L.; Zhang, H.; Wu, S.; Xu, X.; Zhang, L.; Ji, H.; He, L.; Qian, Y.; Wang, Z.; Chen, Y.; Shen, J.^*; Mao, Z.-W.^*; Huang, Z^*. Charge Regulation of Self-Assembled Tubules by Protonation for Efficiently Selective and Controlled Drug Delivery. IScience 2019, 19, 224-231.
36. Liu, M.; Sun, X.; Liao, Z.; Li, Y.; Qi, X.; Qian, Y.; Fenniri, H.; Zhao, P.; Shen, J.^* Zinc oxide end-capped Fe3O4@mSiO2 core-shell nanocarriers as targeted and responsive drug delivery system for chemo-/ions synergistic therapeutics. Drug Delivery 2019, 26, 732-743.
37. Qi, X.; Chen, M.; Qian, Y.; Liu, M.; Li, Z.; Shen, L.; Qin, T.; Zhao, S.; Zeng, Q.; Shen, J.^* Construction of macroporous salecan polysaccharide-based adsorbents for wastewater remediation. International Journal of Biological Macromolecules 2019, 132, 429-438.
38. Qi, X.; Li, Z.; Shen, L.; Qin, T.; Qian, Y.; Zhao, S.; Liu, M.; Zeng, Q.; Shen, J.^* Highly efficient dye decontamination via microbial salecan polysaccharide-based gels. Carbohydrate Polymers 2019, 219, 1-11.
39. Qi, X.; Lin, L.; Shen, L.; Li, Z.; Qin, T.; Qian, Y.; Wu, X.; Wei, X.; Gong, Q.; Shen, J.^* Efficient Decontamination of Lead Ions from Wastewater by Salecan Polysaccharide-Based Hydrogels. ACS Sustainable Chemistry & Engineering 2019, 7, 11014-11023.
40. Qi, X.; Liu, R.; Chen, M.; Li, Z.; Qin, T.; Qian, Y.; Zhao, S.; Liu, M.; Zeng, Q.; Shen, J.^* Removal of copper ions from water using polysaccharide-constructed hydrogels. Carbohydrate Polymers 2019, 209, 101-110. (ESI 1%)
41. Qi, X.; Su, T.; Tong, X.; Xiong, W.; Zeng, Q.; Qian, Y.; Zhou, Z.; Wu, X.; Li, Z.; Shen, L.; He, X.; Xu, C.; Chen, M.; Li, Y.; Shen, J.^* Facile formation of salecan/agarose hydrogels with tunable structural properties for cell culture. Carbohydrate Polymers 2019, 224, 115208.
42. Qi, X.; Wei, W.; Shen, J.^*; Dong, W. Salecan polysaccharide-based hydrogels and their applications: a review. Journal of Materials Chemistry B 2019, 7, 2577-2587.
43. Qian, Y.; Zhao, S.; Shen, H.; Shen, J.^* NanotechnologyAdvances in Medicine:Focus on Cancer. Engineered Science 2019.
44. Sun, X.-Y.; Liu, M.-C.; Chen, X.-L.; Lin, H.-C.; Liu, B.; Peng, Y.-B.; Zhang, L.-Y.; Shen, J.^*; Zhao, P. A dual-targeted nucleic acid moiety decorated SPION nanoparticles for chemo-photodynamic synergistic therapy. Journal of Luminescence 2019, 209, 387-397.
45. Yang, Z.; Sun, Z.; Ren Yi; Xin, C.; Wei, Z.; Zhu, X.; Zongwan, M.; Shen, J.; Nie, S. Advances in nanomaterials for use in photothermal and photodynamic therapeutics Molecular Medicine Reports 2019, 5-20.
46. Zhang, J.; Mai, J.; Li, F.; Shen, J.; Zhang, G.; Li, J.; Hinkle, L. E.; Lin, D.; Liu, X.; Li, Z.; Wang, R.-f.; Mittendorf, E. A.; Ferrari, M.; Shen, H. Investigation of parameters that determine Nano-DC vaccine transport. Biomedical Microdevices 2019, 21, 39.
47. Ding, F.; Qian, Y.; Deng, Z.; Zhang, J.; Zhou, Y.; Yang, L.; Wang, F.; Wang, J.; Zhou, Z.; Shen, J.^*. Size-selected silver nanoparticles for MALDI-TOF mass spectrometry of amyloid-beta peptides. Nanoscale 2018, 10, 22044-22054. (2018 Nanoscale HOT Article Collections)
48. Liu, H.; Mai, J.; Shen, J.; Wolfram, J.; Li, Z.; Zhang, G.; Xu, R.; Li, Y.; Mu, C.; Zu, Y.; Li, X.; Lokesh, G. L.; Thiviyanathan, V.; Volk, D. E.; Gorenstein, D. G.; Ferrari, M.; Hu, Z.; Shen, H. A Novel DNA Aptamer for Dual Targeting of Polymorphonuclear Myeloid-derived Suppressor Cells and Tumor Cells. Theranostics 2018, 8, 31-44.
49. Mu, C.; Wu, X.; Zhou, X.; Wolfram, J.; Shen, J.; Zhang, D.; Mai, J.; Xia, X.; Holder, A. M.; Ferrari, M.; Liu, X.; Shen, H. Chemotherapy sensitizes therapy-resistant cells to mild hyperthermia by suppressing heat shock protein 27 expression in triple negative breast cancer. Clinical Cancer Research 2018, clincanres.3872.2017. (Top Story in Mamarry Cell News)
50. Mu, C.-F.; Shen, J.; Liang, J.; Zheng, H.-S.; Xiong, Y.; Wei, Y.-H.; Li, F. Targeted drug delivery for tumor therapy inside the bone marrow. Biomaterials 2018, 155, 191-202.
51. Shen, J.; Zhang, W.; Qi, R.; Mao, Z.-W.; Shen, H. Engineering functional inorganic-organic hybrid systems: advances in siRNA therapeutics. Chem Soc Rev 2018, 47, 1969-1995. (Front Cover)
52. Sun, J. H.; Zhang, W.; Zhang, D.-Y.; Shen, J.; Tan, C.-P.; Ji, L.-N.; Mao, Z.-W. Multifunctional mesoporous silica nanoparticles as efficient transporters of doxorubicin and chlorin e6 for chemo-photodynamic combinatorial cancer therapy. Journal of Biomaterials Applications 2018, 32, 1253-1264.
53. Wang, F.; Xia, X.; Yang, C.; Shen, J.; Mai, J.; Kim, H.-C.; Kirui, D.; Kang, Y.; an; Fleming, J. B.; Koay, E. J.; Mitra, S.; Ferrari, M.; Shen, H. SMAD4 Gene Mutation Renders Pancreatic Cancer Resistance to Radiotherapy through Promotion of Autophagy. Clinical Cancer Research 2018, 24, 3176.
54. Deng, B.; Xia, M.; Qian, J.; Li, R.; Li, L.; Shen, J.; Li, G.; Xie, Y. Calcium Phosphate-Reinforced Reduction-Sensitive Hyaluronic Acid Micelles for Delivering Paclitaxel in Cancer Therapy. Molecular Pharmaceutics 2017, 14, 1938-1949.
55. Shen, J.; Kim, H.-C.; Wolfram, J.; Mu, C.; Zhang, W.; Liu, H.; Xie, Y.; Mai, J.; Zhang, H.; Li, Z.; Guevara, M.; Mao, Z.-W.; Shen, H. A Liposome Encapsulated Ruthenium Polypyridine Complex as a Theranostic Platform for Triple-Negative Breast Cancer. Nano Letters 2017, 17, 2913-2920. (Top Story in Mamarry Cell News)
56. Shen, J.; Liu, H.; Mu, C.; Wolfram, J.; Zhang, W.; Kim, H.-C.; Zhu, G.; Hu, Z.; Ji, L.-N.; Liu, X.; Ferrari, M.; Mao, Z.-W.; Shen, H. Multi-step encapsulation of chemotherapy and gene silencing agents in functionalized mesoporous silica nanoparticles. Nanoscale 2017, 9, 5329-5341.
57. Shen, J.; Wolfram, J.; Ferrari, M.; Shen, H. Taking the vehicle out of drug delivery. Mater Today (Kidlington) 2017, 20, 95-97.
58. Mu, C.; Wu, X.; Ma, H.; Tao, W.; Zhang, G.; Xia, X.; Shen, J.; Mai, J.; Sun, T.; Sun, X.; Arlinghaus, R. B.; Shen, H. Effective Concentration of a Multikinase Inhibitor within Bone Marrow Correlates with In Vitro Cell Killing in Therapy-Resistant Chronic Myeloid Leukemia. Mol Cancer Ther 2016, 15, 899-910.
59. Scott, B.; Shen, J.; Nizzero, S.; Boom, K.; Persano, S.; Mi, Y.; Liu, X.; Zhao, Y.; Blanco, E.; Shen, H.; Ferrari, M.; Wolfram, J. A pyruvate decarboxylase-mediated therapeutic strategy for mimicking yeast metabolism in cancer cells. Pharmacological Research 2016, 111, 413-421.
60. Wolfram, J.; Scott, B.; Boom, K.; Shen, J.; Borsoi, C.; Suri, K.; Grande, R.; Fresta, M.; Celia, C.; Zhao, Y.; Shen, H.; Ferrari, M. Hesperetin Liposomes for Cancer Therapy. Curr Drug Deliv 2016, 13, 711-719.
61. Xu, R.; Zhang, G.; Mai, J.; Deng, X.; Segura-Ibarra, V.; Wu, S.;         Shen, J.; Liu, H.; Hu, Z.; Chen, L.; Huang, Y.; Koay, E.; Huang, Y.; Liu, J.; Ensor, J. E.; Blanco, E.; Liu, X.; Ferrari, M.; Shen, H. An injectable nanoparticle generator enhances delivery of cancer therapeutics. Nature Biotechnology 2016, 34, 414-418. (Hot Paper, ESI 1%)
62. Zhang, W.; Shen, J.; Su, H.; Mu, G.; Sun, J.-H.; Tan, C.-P.; Liang, X.-J.; Ji, L.-N.; Mao, Z.-W. Co-Delivery of Cisplatin Prodrug and Chlorin e6 by Mesoporous Silica Nanoparticles for Chemo-Photodynamic Combination Therapy to Combat Drug Resistance. ACS Applied Materials & Interfaces 2016, 8, 13332-13340.
63. Shen, J.; Wu, X.; Lee, Y.; Wolfram, J.; Yang, Z.; Mao, Z.-W.; Ferrari, M.; Shen, H. Porous Silicon Microparticles for Delivery of siRNA Therapeutics. JoVE 2015, e52075.
64. Wolfram, J.; Zhu, M.; Yang, Y.; Shen, J.; Gentile, E.; Paolino, D.; Fresta, M.; Nie, G.; Chen, C.; Shen, H.; Ferrari, M.; Zhao, Y. Safety of Nanoparticles in Medicine. Current Drug Targets 2015, 16, 1671-1681.
65. Shen, J.; Kim, H.-C.; Mu, C.; Gentile, E.; Mai, J.; Wolfram, J.; Ji, L.-n.; Ferrari, M.; Mao, Z.-w.; Shen, H. Multifunctional Gold Nanorods for siRNA Gene Silencing and Photothermal Therapy. Advanced Healthcare Materials 2014, 3, 1629-1637.
66. Shen, J.; Kim, H.-C.; Su, H.; Wang, F.; Wolfram, J.; Kirui, D.; Mai, J.; Mu, C.; Ji, L.-N.; Mao, Z.-W.; Shen, H. Cyclodextrin and polyethylenimine functionalized mesoporous silica nanoparticles for delivery of siRNA cancer therapeutics. Theranostics 2014, 4, 487-497. (ESI 1%)
67. Wolfram, J.; Suri, K.; Yang, Y.; Shen, J.; Celia, C.; Fresta, M.; Zhao, Y.; Shen, H.; Ferrari, M. Shrinkage of pegylated and non-pegylated liposomes in serum. Colloids and Surfaces B: Biointerfaces 2014, 114, 294-300.
68. Wolfram, J.; Yang, Y.; Shen, J.; Moten, A.; Chen, C.; Shen, H.; Ferrari, M.; Zhao, Y. The nano-plasma interface: Implications of the protein corona. Colloids and Surfaces B: Biointerfaces 2014, 124, 17-24.
69. Shen, J.; Xu, R.; Mai, J.; Kim, H.-C.; Guo, X.; Qin, G.; Yang, Y.; Wolfram, J.; Mu, C.; Xia, X.; Gu, J.; Liu, X.; Mao, Z.-W.; Ferrari, M.; Shen, H. High capacity nanoporous silicon carrier for systemic delivery of gene silencing therapeutics. ACS nano 2013, 7, 9867-9880. (ESI 1%)
70. Yang, Y.; Shen, J.; Yu, X.; Qin, G.; Zhang, M.; Shen, H.; Mao, Z.; Ferrari, M. Identification of an inhibitory mechanism of luteolin on the insulin-like growth factor-1 ligand-receptor interaction. Chembiochem 2013, 14, 929-933.
71. Yang, Y.; Wolfram, J.; Shen, J.; Zhao, Y.; Fang, X.; Shen, H.; Ferrari, M. Live-cell single-molecule imaging reveals clathrin and caveolin-1 dependent docking of SMAD4 at the cell membrane. FEBS Lett 2013, 587, 3912-3920.
72. Tan, L.; Shen, J.; Liu, J.; Zeng, L.; Jin, L.; Weng, C. Spectral characteristics, DNA-binding and cytotoxicity of two functional Ru(ii) mixed-ligand complexes. Dalton Transactions 2012, 41, 4575-4587.
73. Tan, L.-F.; Chen, X.-J.; Shen, J.; Liang, X.-L. Synthesis, DNA-binding and photocleavage studies of Ru(II) complexes of phenyl-(4,5,9,14-tetraaza-benzo[b]triphenylen-1,1-yl)-methanone. Journal of Chemical Sciences 2009, 121, 397-405.
74. Tan, L.-F.; Liu, J.; Shen, J.; Liu, X.-h.; Zeng, L.-L.; Jin, L.-H. First Ruthenium(II) Polypyridyl Complex As a True Molecular “Light Switch” for Triplex RNA Structure: [Ru(phen)₂(mdpz)]²⁺ Enhances the Stability of Poly(U)·Poly(A)*Poly(U). Inorganic Chemistry 2012, 51, 4417-4419.
75. Tan, L.-F.; Shen, J.; Chen, X.-J.; Liang, X.-L. In vitro study on DNA binding of ruthenium(II) complexes with polypyridyl ligands. DNA and Cell Biology 2012, 28, 461-468.

1. 温州医科大学重大项目培育工程、KYWY201901、微环境响应的siRNA载体制备和应用、202001-202312、55万、在研、本人作用(主持)。
2. 中国科学院大学温州研究院新型冠状病毒感染肺炎应急科研公关项目、WIUCASYJ200001-2、202003-202101、30万、在研、本人作用(主持)。
3. 国家自然科学基金面上项目、21977801、肿瘤微环境逐级靶向的小干扰RNA载体制备及康三阴性乳腺癌活性的研究、202001-202312、66万、在研、本人作用(主持)。
4. 温州市基础项目、Y20190054、多级靶向近红外纳米探针用于介导管胰腺癌早期诊断的研究、202001-202106、3万、在研、本人作用(主持)。
5. 国家自然科学基金青年项目、31800833、多核铂类配合物与siRNA自组装纳米粒的制备及活性研究、201901-202112、27万、在研、本人作用(主持)。
6. 浙江省自然基金重点项目、LZ19H180001、多级靶向响应肿瘤微环境的小干扰RNA载体构建及抗三阴性乳腺癌活性研究、201901-202212、35万、在研、本人作用(主持)。
7. 温州市基础项目、Y20180071、多级靶向小干扰RNA载体构建及抗三阴性乳腺癌活性研究、201901-202012、3万、在研、本人作用(主持)。
8. 温州市产学研项目、顺铂衍生物与siRNA自组装纳米颗粒的制备与抗癌活性研究、201806-202005、2万、在研、本人作用(主持)。
9. 温州医科大学启动项目、QTJ18119、肿瘤微环境响应的功能化材料设计与应用、201805-202305、150万、在研、本人作用(主持)。
10. 温州生物材料与工程研究所重大专项、WIBEZD2017001-03、肿瘤微环境多级响应的功能化材料设计与应用、201709-202208、150万、在研、本人作用(主持)。
11. 国家自然科学基金重点项目、20231007、环糊精功能化无机纳米材料的构建及其介导的肿瘤多靶点治疗研究、201301-201712、320万、结题、本人作用(参与)。
12. 国家自然科学基金面上项目、21272285、多齿NHC卡宾高价过度金属配合物的合成及其催化性质研究、201301-2016.12、80万、结题、本人作用(参与)。
13. The National Institute of Health (RO1), 1R01CA193880-01A1, Tumor Vasculature-targeted Nanotherapeutics for DNA Damage Response, 201512-202011, $1824280，结题、本人作用(参与)。
14. Department of Defense, U54CA151668, Multistage vector-enabled breast oncology, 2012.9-2017.9, $3110000，结题、本人作用(参与)。
15. Nationals Cancer Institute (U54), U54CA143837, Texas Center for Cancer Nanomedicine, 2010.9-2015.8, $12120815，结题、本人作用(参与)。

1. 沈建良、叶方富、何晓俊，一种金属卟啉配合物制备及其应用，7。
2. 沈建良、叶方富、齐晓亮，一种多糖基杂化水凝胶的制备及应用，4。
3. 李志鹏、沈建良， 一种特异性识别还原型GSH的罗丹明类荧光探针及其制备方法与应用，2020102412694
4. 钱宇娜、沈建良，一种双重交联的多功能水凝胶敷料及其制备和用途，2020106387649
5. 钱宇娜、沈建良， 一种含氧水凝胶敷料及其制备和用途 ，2020106386504
6. 沈建良、赵圣哲，一种制备小尺寸单分散氧化铋的方法，0
7. 赵圣哲、沈建良，一种制备二维氧化铋纳米片的方法，1
8. 钱宇娜、沈建良，一种脂质体包封的钌多吡啶配合物及其应用，20
9. 何晓俊、沈建良。一种小分子荧光探针及其制备方法与应用， 2019108137490。
10. 何晓俊、沈建良。基于聚集诱导发光小分子荧光探针及其制备方法及应用，2019111262091。
11. 何晓俊、沈建良、范金益。一种关-开型分子荧光探针CMTAH及其制备方法与应用， 2019112948370。
12. 沈建良、何晓俊。一种以3-羟基黄酮为荧光团的小分子荧光探针及其制备方法与应用，X
13. 钱宇娜、沈建良，一种环糊精-介孔硅多功能纳米载药颗粒，00
14. 沈建良、赵平、柳敏超、钱宇娜，一种多功能核壳结构Fe3O4@TiO2@ZiF-8纳米粒子载药体系及制备方法，40
15. 沈建良、钱宇娜， 一种肿瘤微环境多级响应的基因药物载体及使用方法，50
16. 沈建良、钱宇娜，一种铂类衍生药物自我递送基因药物载体及其使用方法，70
17. 沈建良、陈洪、钱宇娜，一种治疗口腔溃疡的中药配方及其治疗方法，50
18. 何晓俊、沈建良，一种小分子探针H4L及其制备方法和应用，80
19. 何晓俊、沈建良，一种小分子探针及其制备方法与应用，00
20. 沈建良、何晓俊，一种以CS为荧光团的小分子荧光探针及其制备方法与应用，90
21. 沈建良、何晓俊，一种以TS为荧光团的小分子荧光探针及其制备方法与应用，00
22. 沈建良、钱宇娜、齐若谷，一种共聚胶束载药纳米颗粒及其应用，2018113921027
23. Haifa Shen，Mauro Ferrari，Jianliang Shen，Mingzhen Zhang， Polycation-functionalized nanoporous silicon carrier for systemic delivery of gene silencing agents，U20160369269A1 (US)

担任Nature Sustainability, Coordination Chemistry Reviews,  Theranostics,  Nanoscale, Angewandte International Edition Chemie和 ACS Nano 等30余个SCI杂志的独立审稿人，同时担任American Journal of Nanotechnology &Nanomedicine荣誉主编, Chinese Chemical Letters (中国化学快报）青年编委会委员，Advanced Applied Materials 主编。

1. 沈建良，谭彩萍，毛宗万*，计亮年。四核钌配合物与人体G-四链体相互作用及体外抗肿瘤活性研究。第十一届全国生物无机化学学术会议论文摘要集，2011，河北，保定，发表会议论文。
2. Jian-Liang Shen, Hua Su, Liang-Nian Ji, Zong-Wan Mao*, Hai-Fa Shen*. High Capacity Nanoporous Silicon Carrier for Systemic Delivery of Gene Silencing Therapeutics. 第12届国际应用生物无机化学学术研讨会论文摘要集，2013，中国，广州，发表会议论文。
3. Yuna Qian, Zong-Wan Mao,Jian-Liang Shen*. Engineering Functional Inorganic-Organic Hybrid System Advances in siRNA Therapeutics. 2018年中西部地区无机化学化工学术研讨会，2018，中国，武汉，发表会议论文。
4. 邀请口头报告，Mesoporous Silica Nanoparticles for siRNA Delivery, 2014 MAPTA Traveling Award. 2014，美国，休斯顿。
5. 邀请口头报告，Taking the Vehicle Out of Drug Delivery: Green Nanotherapeutics. 2017南湖学术论坛（生物无机化学研究前沿和发展战略论坛)，2017，中国，嘉兴。
6. 口头报告，Engineering Functional Inorganic-Organic Hybrid System Advances in siRNA Therapeutics. 中国地31届化学年会生物无机化学分会，2018，中国，杭州。
7. 邀请报告，Engineering Functional Inorganic-Organic Hybrid System Advances in siRNA Therapeutics.  湘潭大学化学学院，2017，中国，湘潭。
8. 邀请报告，Engineering Functional Inorganic-Organic Hybrid SystemAdvances in siRNA Therapeutics.  湖南科技大学，2017，中国，湘潭。
9. 邀请报告，Theranostic Inorganic-Organic Hybrid System Advances in Cancer Therapeutics.  湖南工业大学，2018，中国，株洲。
10. 邀请报告，Theranostic Inorganic-Organic Hybrid System Advances in Cancer Therapeutics. WIBE千人论坛，2018，中国，温州。
11. 邀请报告，Theranostic Inorganic-Organic Hybrid System Advances in Drug Delivery.  洛阳师范学院，2018，中国，洛阳。
12. 口头报告， Functional Inorganic-Organic Hybrid Nanoparticles for Biomedical Applications. 第十四届全国生物无机化学学术会议，2018，中国，南京
13. 邀请报告，Engineering Functional Inorganic-Organic Hybrid System Advances in Triple Negative Breast Cancer Therapeutics，郑州大学, 2018，中国，郑州
14. 邀请报告，Engineering Functional Inorganic-Organic Hybrid System Advances in Triple Negative Breast Cancer Therapeutics，周口师范学院, 2019，河南，周口
15. 邀请报告，Engineering Functional Inorganic-Organic Hybrid Nanomaterials for Biomedical Applications，2019 “WIBE医学与健康”论坛，2019，中国，温州
16. 邀请报告，Engineering Functional Inorganic-Organic Hybrid System Advances in Triple Negative Breast Cancer Therapeutics，2019年全国肿瘤会（纳米肿瘤青年论坛），中国，重庆
17. 邀请报告，Engineering Functional Inorganic-Organic Hybrid System Advances in Triple Negative Breast Cancer Therapeutics，上海交通大学，2019，中国，上海
18. 邀请报告，Engineering Functional Inorganic-Organic Hybrid System Advances in Triple Negative Breast Cancer Therapeutics，上海中医药大学, 2019，中国，上海
19. 邀请报告，Engineering Functional Inorganic-Organic Hybrid System Advances in Cancer Therapeutics，华南师范大学, 2019，中国，广州
20. 邀请报告，Engineering Functional Inorganic-Organic Hybrid System Advances in Triple Negative Breast Cancer Therapeutics，中山大学, 2019，中国，广州
21. 邀请报告， Functional Inorganic-Organic Hybrid System Advances in Cancer Therapeutics，昆明理工大学, 2019，中国，昆明