Bioactive Materials Research Group

李花琼博士毕业于新加坡南洋理工大学，先后在新加坡南洋理工大学和南洋理工学院等机构从事科研工作，现任中国科学院大学温州研究院课题组负责人、温州医科大学兼聘硕士生导师。主要研究方向为生物材料与细胞的相互作用以及其在组织工程和再生医学领域的应用。目前已在生物材料领域知名期刊（如ACS Applied Materials and Interfaces，Acta Biomaterialia，Chemical Engineering Journal，Journal of Materials Chemistry B等）发表SCI论文20余篇。2015年回国工作后，主持国家、省市厅级项目等5项，总计经费达500余万。已申请发明专利6项（授权1项），并创立温州优墨生物科技有限公司，获得温州市留学人员创业资金项目资助。曾入选科技部中国-澳大利亚青年科学家交流计划、温州市580海外精英引进计划和温州市551人才工程。还获得科技部中国-克罗地亚科技合作委员会第九届例会交流项目的资助。

2013 Ph.D. in Biomaterials, Nanyang Technological University, Singapore

1.2014-01 ~ 2015-03: Project Engineer, Nanyang Polytechnic, Singapore

• Risk assessment of ultrafine particles (UFPs) in the indoor air
• High-throughput screening for particles and chemicals toxicity

2.2013-01 ~ 2014-01:   Project Officer, Nanyang Technological University, Singapore

• Finite Element Analysis of structural cells used for tree planting in constrained spaces
• Engineering micro-nano hybrid grafts using micro-contact printing and electrospinning method

3.2009-01 ~ 2013-01:  Ph.D. candidate, Biomaterials, Nanyang Technological University, Singapore

• Laser machining of different micropatterns on the surface of bio-polymers
• The effect of microtopology on stem cells and its implication in tissue engineering

1. Xenogeneic biological materials: use gene knockout pigs and 3D printing technology to develop xenogeneic bone/cartilage repair materials;
2. Biological interface: Use various technologies to modify the surface of biological materials and observe the interaction between cells and materials. Mainly study the impact of the physical characteristics of the cell microenvironment on cell growth, such as stem cell differentiation, cell aging, etc.;
3. Nanomedicine: Construct a targeted nanomedicine delivery system for related research on tumor treatment.

1. W.T. Sow, F. Ye, C. Zhang,  H. Li,*Smart materials for point-of-care testing: From sample extraction to analyte sensing and readout signal generator. Biosens Bioelectron, 170, 112682, 2020.
2. H. Li,*Y. Hou, L. Li. Tunable design of yolk-shell ZnFe2O4@C composites for enhancing electromagnetic wave absorption. Powder Technol 378, 216, 2021.
3. L. Zhang, C. Mu, T. Zhang, Y. Wang, Y. Wang, L. Fan, C. Liu, H. Chen, J. Shen, K. Wei, H. Li,* Systemic Delivery of Aptamer Conjugated XBP1 siRNA Nanoparticle for Efficient Suppression of HER2+ Breast Cancer. ACS Appl Mater Interfaces,12, 32360, 2020.
4. Q. Pan, C. Gao, Y. Wang, Y. Wang, C. Mao, Q. Wang, S.N. Economidou, D. Douroumis, F. Wen, L.P. Tan, H. Li.* Investigation of bone reconstruction using an attenuated immunogenicity xenogenic composite scaffold fabricated by 3D printing. Bio-Design & Manufacturing, 3, 396, 2020.
5. H. Li, C. Gao, L. Tang, C. Wang, Q. Chen, Q. Zheng, S. Yang, S. Sheng, X. Zan. Lysozyme (Lys), tannic acid (TA), and graphene oxide (GO) thin coating for antibacterial and enhanced osteogenesis. ACS Appl Bio Mater 3, 673, 2020.
6. T. Zhu, J. Mao, Y. Cheng, H. Liu, L. Lv, M. Ge, S. Li, J. Huang, Z. Chen, H. Li,* L. Yang, Y. Lai. Recent Progress of Polysaccharide-Based Hydrogel Interfaces for Wound Healing and Tissue Engineering. Adv Mater Interfaces 1900761, 2019.
7. M. Li, ^# H. Li, ^# Q. Pan, C. Gao, Y. Wang, S. Yang, X. Zan, Y. Guan. Graphene oxide and lysozyme ultrathin films with strong antibacterial and enhanced osteogenesis. Langmuir 35, 6752, 2019.
8. C. Gao, L. Tang, J. Hong, C. Liang, L.P. Tan, H. Li.* Effect of laser induced topography with moderate stiffness on human mesenchymal stem cell behavior. J Phys Mater 2, 034006, 2019.
9. Y.S. Lui, W.T. Sow, L.P. Tan, Y. Wu, Y. Lai, H. Li.* 4D Printing and Stimuli-responsive Materials in Biomedical Aspects. Acta Biomater 92, 19, 2019.
10. Y. Wang, B.H. Lee, Allan Z. Zhao, H. Li.* Biomaterials in Bone Tissue Engineering. Mater Sci Technol DOI: 10.1002/9783527603978.mst0481, 2019.
11. H. Li,* Y. Hou, L. Li. Synthesis of the SiO₂@C composites with high-performance electromagnetic wave absorption. Powder Technol 343, 129, 2019.
12. Z.S. Huang; Y.Y. Quan; J.J. Mao; Y.L. Wang; Y. Lai; J. Zheng; Z. Chen; K. Wei; H. Li.* Multifunctional superhydrophobic composite materials with remarkable mechanochemical robustness, stain repellency, oil-water separation and sound-absorption properties. Chem Eng J 358, 1610, 2019.
13. H. Li,* Q. Ye, M. Su. Application of Stem Cells and Advanced Materials in Nerve Tissue Regeneration. Stem Cells Intl 4243102, 2018.
14. L. Luo, Y. He, X. Wang, B. Key, B.H. Lee, H. Li,* Q. Ye. Potential Roles of Dental Pulp Stem Cells in Neural Regeneration and Repair. Stem Cells Intl 1731289, 2018.
15. Q. Wang, J. Huang, H. Li, * Allan Z. Zhao, Y. Wang, K. Zhang, H. Sun, Y. Lai. Recent advances in smart TiO₂ nanotube platforms for sustainable drug delivery applications. Intl J Nanomed 12, 151, 2017.
16. M. L. Chua,^# M. I. Setyawati,^# H. Li,^# C.Y.F. Hay, S. Gurusamy, F. Teoh, D. T. Leong, S. George. Particulate matter from indoor environments of classroom induced higher cytotoxicity and leakiness in human microvascular endothelial cells in comparison to those collected from corridor. Indoor Air 27, 551, 2017.
17. H. Li,* F. Wen, H. Chen, M. Pal, Y. Lai, Allan Z. Zhao, L.P. Tan. Micropatterning extracellular matrix proteins on electrospun fibrous substrate promote human mesenchymal stem cell differentiation toward neurogenic lineage. ACS Appl Mater Interfaces 8, 563, 2016.
18. H. Li, C.Y.F. Hay, W. Shi, S. Gurusamy, S. Li, M.N. Krishnan, S. George. Size and site dependent biological hazard potential of particulate matters collected from different heights at the vicinity of a building construction. Toxicol Lett 238, 20, 2015.
19. H. Li,* F. Wen, X. Wang, L.P. Tan. Role of RhoA/Rho kinase signaling pathway in microgroove induced stem cell myogenic differentiation. Biointerphases 10, 021003, 2015.
20. H. Li, Y. Lai, J. Huang, Y. Tang, L. Yang, Z. Chen, K.Q. Zhang, X. Wang, L.P. Tan. Multifunctional wettability pattern prepared by laser processing on superhydrophobic TiO₂ nanostructured surfaces. J Mater Chem B 3, 342, 2015. (Inside back cover highlighted)
21. H. Li, Y.S. Wong, F. Wen, K.W. Ng, Gary K.L. Ng, Subbu S. Venkatraman, Freddy Y.C. Boey, L.P. Tan, Human mesenchymal stem cell behaviour on direct laser micropatterned electrospun scaffolds with hierarchical structures. Macromol Biosci 13, 299, 2013.
22. H. Li, F. Wen, Y.S. Wong, Y.C. Freddy Boey, Venkatraman S. Subbu, David T. Leong, K.W. Ng, Gary K.L. Ng, L.P. Tan, Direct laser machining induced topographic pattern promotes human mesenchymal stem cell differentiation towards myogenic lineage. Acta Biomater 8, 531, 2012.
23. H. Li, H. Xian, G. Zhao, Synthesis and crystal structures of La(III), Y(III) complexes of homoveratric acid with 1,10-phenanthroline. J Rare Earths 28, 7, 2010.
24. H. Li, X. Zhao, X. Hu, G. Zhao. Synthesis, characterization, crystal structure and non-isothermal dehydration kinetics of the copper(II) complex. J Coord Chem 61, 3493, 2008.