邓俊杰，博士

  • 职位:
    研究生导师
  • 学院:
    理工学院

学术任职

SCI 杂志IET Nanobiotechnology 副主编

人才头衔

钱江人才、浙江省杰出青年基金获得者、温州市特支计划青年拔尖人才

教育与工作经历

  1. 2017/06-至今 中国科学院大学温州研究院（温州生物材料与工程研究所）课题组PI 、研究员
  2. 2016/03-2017/06 美国东北大学（Northeastern University）化工学院博士后 合作老师：Prof. Ming Su
  3. 2014/02-2016/02 德雷塞尔大学（Drexel University）材料科学与工程系博士后 合作老师：Prof. Hao Cheng
  4. 2011/07-2013/12 苏州大学高分子科学与工程师资博士后 合作老师：蔡远利教授
  5. 2008/09-2011/06 中山大学高分子化学与物理理学博士 指导老师：张黎明教授；
  6. 2005/09-2008/06 湘潭大学高分子化学与物理理学硕士 指导老师：蔡远利教授

研究兴趣

近年来课题组研究方向主要围绕以生命体自身组织和细胞为来源开发可调控免疫细胞的生物材料，探索其在组织再生、异体移植和肿瘤免疫治疗方面的应用，并进一步实现临床转化。具体方向如下：

  1. 自体细胞组织源生物材料的开发及在组织再生和异体移植方面的应用；
  2.  细胞衍生微/纳米凝胶的制备及在胶质瘤治疗方面的应用；
  3. 具仿生结构的微纳米表界面材料清除循环血液中病原菌的研究；

学术论文

  1. Zhongxing Chen, Mei Yang, Qing Wang, Jieyi Bai, Colm McAlinden, Eirini Skiadaresi, Jun Zhang, Luting Pan, Chenyang Mei, Zhenhai Zeng, Jinjin Yu, Yifan Feng, Zhengxuan Jiang, Wenjin Xu, Hang Xu, Xiuhong Ye, Huanhuan He, Qinmei Wang,* Junjie Deng*, Jinhai Huang*, Hydrogel eye drops as a non-invasive drug carrier for topical enhanced Adalimumab permeation and highly efficient uveitis treatment. Carbohydrate Polymers, 2021, 253, 117216.
  2. Ji Wang, Xia Wu, Peng Shen, Jun Wang, Yidan Shen, Yan Shen, Thomas J. Webster*, Junjie Deng*, Applications of Inorganic Nanomaterials in Photothermal Therapy Based Combinational Cancer Treatment.(Review) International Journal of Nanomedicine, 2020, 15, 1903-1914.
  3. Zhiyuan Fan†, Junjie Deng†, Peter Y. Li, Daphney R. Chery, Yunfei Su, Pu Zhu, Taku Kambayashi, Elizabeth P. Blankenhorn, Lin Han, Hao Cheng, A new class of biological materials: Cell membrane-derived hydrogel scaffolds. Biomaterials, 2019, 197, 244-254. (†Co-first author)
  4. Ru Wang†, Junjie Deng†, Dongsheng He, Ershuang Yang, Wenqian Yang, Di Shi, Yanni Jiang, Zijie Qiu, Thomas J. Webster, Yan Shen, PEGylated hollow gold nanoparticles for combined X-ray radiation and photothermal therapy in vitro and enhanced CT imaging in vivo. Nanomedicine: Nanotechnology, Biology, and
    Medicine, 2019, 16, 195-205.(†Co-first author)
  5. Junjie Deng,* Xiaojie Xun, Wenjun Zheng, Yunfei Sun, Liyuan Zheng, Chenfei Wang, Ming Su, Sequential delivery of bismuth nanoparticles and doxorubicin by injectable macroporous hydrogel for combined kilovoltage X-ray radio- and chemo-therapy of breast cancer. J. Mater. Chem. B, 2018, 6, 7966-7973.
  6. Junjie Deng, Shandong Xu, Weike Hu, Xiaojie Xun, Liyuan Zheng, Ming Su, Tumor targeted, stealthy and degradable bismuth nanoparticles for enhanced X-ray radiation therapy of breast cancer. Biomaterials, 2018, 154, 24-33.
  7. Hao Zhou, Zhiyuan Fan, Peter Y. Li, Junjie Deng, Dimitrios C. Arhontoulis, Christopher Y. Li, Wilbur B. Bowne, Hao Cheng, ACSNano, 2018, 12, 10130-10141.
  8. Li Jiao, Qingxuan Li, Junjie Deng, Nsikak Okosi, Junfei Xia, Ming Su, Nanocellulose templated growth of ultra-small bismuth nanoparticles for enhanced radiation therapy. Nanoscale, 2018, 10, 6751-6757.
  9. Zhiyuan Fan, Peter Y. Li, Junjie Deng, Stephen C. Bady, Hao Cheng, Cell membrane coating for reducing nanoparticle-induced inflammatory responses to scaffold constructs. Nano Research, 2018, 11, 5573-5583.
  10. Guan-Hai Wang, Guo-Liang Huang, Yi Zhao, Xing-Xiang Pu, Tong Li, Jun-Jie Deng*, Jian-Tao Lin*, ATP triggered drug release and DNA co-delivery systems based on the ATP responsive aptamers and polyethylenimine complexes. J. Mater. Chem. B, 2016, 4, 3832-3841.
  11. Hao Zhou, Zhiyuan Fan, Junjie Deng, Pelin K. Lemons, Dimitrios C. Arhontoulis, Wilbur B. Bowne, Hao Cheng, Hyaluronidase embedded in nanocarrier PEG shell for enhanced tumor penetration and highly efficient antitumor efficacy. Nano Lett. 2016, 16, 3268-3277.
  12. Yanfang Zhou, Jiemei Li, Fang Lu, Junjie Deng, Jiahua Zhang, Peijie Fang, Xinsheng Peng, Shu-Feng Zhou. A study on the hemocompatibility of dendronized chitosan derivatives in red blood cells. Drug Design, Development and Therapy, 2015, 9 2635-2645.
  13. Na Li, Heng-Cong Luo, Chuan Yang, Junjie Deng, Meng Ren, Xiao-Ying Xie, Diao-Zhu Lin, Li Yan, Li-Ming Zhang, Cationic star-shaped polymer as a siRNA carrier for reducing MMP-9 expression in skin fibroblast cells and promoting wound healing in diabetic rats. International Journal of Nanomedicine, 2014, 9,
    3377-3387.
  14. Junjie Deng, Yuanli Cai, Botryoid-shaped reactive nanoparticles through spontaneous structural reorganization of terpolymer micelles. Macromol. Rapid Commun., 2013, 34, 1459-1463.
  15. Bin Liang,† Junjie Deng,† Wei Li, Li-ming Zhang, Cong Gao, Efficient gene transfection in the neurotypic cells by star-shaped polymer consisting of β-cyclodextrin core and poly (amidoamine) dendron arms. Carbohydrate Polymers, 2013, 94, 185-192. (†Co-first author)
  16. Zhilin Liu, Yufang Tang, Nan Li, Lican Lu, Junjie Deng, Yuanli Cai, Modulating light-tunable acid sensitivity of a bioinspired polymer simply by adjusting the position of a single methoxy substituent. J Polym Sci Part A: Polym Chem, 2012, 50, 495-508.
  17. Junjie Deng, Na Li, Kaijin Mai, Chuan Yang, Li Yan, Li-Ming Zhang, Star-shaped polymers consisting of β-cyclodextrin core and poly(amidoamine) dendron arms: Binding and release studies with methotrexate and siRNA. J. Mater. Chem., 2011, 21, 5273-5281.
  18. Junjie Deng, Ying Luo, Li-ming Zhang, PEGylated polyamidoamine dendron-assisted encapsulation of plasmid DNA into in-situ forming supramolecular hydrogel. Soft Matter, 2011, 7, 5944-5947.
  19. Junjie Deng,† Yanfang Zhou,† Bo Xu, Kaijin Mai, Yubin Deng, Li-Ming Zhang, Dendronized chitosan derivative as a biocompatible gene delivery carrier. Biomacromolecules, 2011, 12, 642-649.
  20. Ke Yang, Xiangqian Wei, Fen Wu, Chaowei Cao, Junjie Deng, Yuanli Cai, Sequence control over thermo-triggered micellization and smart nanogels of copolymers based on PEGMA and aldehyde-functionalized monomer. Soft Matter, 2011, 7, 5861-5872.
  21. Jun Sun, Yifeng Peng, Ying Chen, Yu Liu, Junjie Deng, Lican Lu, Yuanli Cai, Effect of molecular structure on thermoresponsive behaviors of pyrrolidone-based water-soluble polymers. Macromolecules, 2010, 43, 4041-4049.
  22. Yuanli Cai, Lican Lu, Wending Jiang, Haijia Zhang, Junjie Deng, Yaohua Li, Yi Shi. Environentally friendly and controlled radical polymerization. Progress In Chemistry, 2010, 22,1490-1498.
  23. Shanshan Jia, Junjie Fei, Junjie Deng, Yuanli Cai, Junan Li, Direct electrochemistry and lectrocatalysis of hemoglobin immobilized in an amphiphilic diblock copolymer film. Sensors and Actuators B: Chemical, 2009,
    138(1), 244-250.
  24. Junjie Deng, Yi Shi, Wending Jiang, Yifeng Peng, Lican Lu, Yuanli Cai, Facile synthesis and thermo-responsive behaviors of a well-defined pyrrolidone based hydrophilic polymer. Macromolecules, 2008, 41, 3007-3014.
  25. Haijia Zhang, Junjie Deng, Lican Lu, Yuanli Cai, Ambient-temperature RAFT polymerization of styrene and its functional derivatives under mild long-wave UV-vis radiation. Macromolecules, 2007, 40, 9252-9261.
  26. Hongmei Kang, Yuanli Cai, Junjie Deng, Haijia Zhang, Yufang Tang, Pengsheng Liu, Synthesis and aqueous solution behavior of phosphonate-functionalized chitosans. European Polymer Journal, 2006, 42, 2678-2685.

英文专著

Junjie Deng, Peter Y. Li, Hao Cheng. CHAPTER 10: Advances of Smart Materials for Wound Healing. Applications of Smart Materials in Tissue Engineering, 2017, The Royal Society of Chemistry Publication.

发明专利

  1. 邓俊杰，麦开锦，张黎明. 一种树枝化壳聚糖衍生物及其制备方法(授权号: ZL 201010515991.9).
  2. 邓俊杰，张黎明. 一种两亲性壳聚糖衍生物及其制备方法和应用(授权号: ZL 201110156977.9).
  3. 邓俊杰，袁珊珊，寻晓洁. 具微米多孔结构的富血小板裂解液血浆基水凝胶(公开号: CN201810592947.4)
  4. 邓俊杰，王辰飞. 具有双层不同内部孔径结构的蛋白基水凝胶及其制备方法(公开号: CN201811382935.5)
  5. 邓俊杰，王震，徐伟德. 基于动态化学键交联的纳米凝胶及其制备方法与应用(公开号: CN202010060891.5)
  6. 邓俊杰，张常欢，黄锦海，陈中幸，张双喆. 红细胞膜基水凝胶接触镜及其制备方法和应用(公开号: CN202010115836.1)
  7. 邓俊杰，袁珊珊，寻晓洁. 一种益生菌代谢产物基水凝胶及其制备方法(公开号: CN202010326184.6)
  8. 邓俊杰，蒋卫中，杨惠康. 一种超耐磨长效抗菌抗病毒纳米涂料及其制备方法(202010640905.0)
  9. 苏云飞，邓俊杰，郑莉媛. 中空且多级孔壁二氧化铈的制备方法(公开号: CN2017112898940)

主持项目

  1. 国家自然科学基金面上项目2020-2023, 31971260, 58 万
  2. 浙江省自然科学基金杰出青年基金项目2020-2023, R20C100001，80 万
  3. 浙江省自然科学基金一般面上项目2019-2021, LY19C100002，10 万
  4. 浙江省骨科重点实验室开放基金2019-2020, ZJGK1804Y，3 万
  5. 中国科学院大学温州研究院重大科研启动项目2017-2020, WIBEZD2017003-04，300 万
  6. 中国博士后科学基金项目2011-2013, 2012M511314，5 万
  7. 温州市级基础性科研项目2020-2022, Y20190136，3 万
  8. 中国科学院大学温州研究院新型冠状病毒感染肺炎防治应急科研攻关项目子课题2020-2021, WIUCASYJ2020001-3，30 万
  9. 中山市科技发展专项资金2020-2023，500 万
  10. 国家卫健委-浙江省医药卫生重点科技项目2020-2022，WKJ-ZJ-2019（合作），30 万

会议口头报告

  1. “具有高效siRNA 转染的新型聚合物基因载体”，中国生物材料大会，成都，2010 年；
  2. “细胞膜衍生大孔水凝胶调控巨噬细胞表型转化”，中国生物材料大会，大连，2019 年，分会主席；
  3. “具调控巨噬细胞功能的细胞组分衍生大孔凝胶”，海峡两岸暨港澳生物材料与组织再生青年科学家学术会议，2002 年，邀请报告；

获奖情况

  1. 2008/05, 湘潭大学2008 界优秀毕业研究生
  2. 2008/06, 湘潭大学第十三界研究生校长奖优秀奖
  3. 2011/06, 2011 中山大学芙兰学生优秀论文奖二等奖
  4. 2017/06, Materials Science and Engineering: C 期刊杰出审稿人
  5. 2018/03, Chemical Engineering Journal 期刊杰出审稿人
  6. 2018/04, Carbohydrate Polymers 期刊杰出审稿人
  7. 2018 年, 温州创新创业大赛总决赛三等奖
  8. 2018 年, 温州市创新创业大赛浙南科技城分赛初创组一等奖
  9. 2019 年, 温州市科技创新青年拔尖人才

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