集机械，材料和生物医药工程的三学科背景，从事生物再生医药材料的研发项目运行管理，研究中心的建立，及科研院校博士及本科生的指导。
毕业于新加坡国立大学杨潞龄医学院生物工程专业，曾任新加坡国立大学杨潞龄医学院研究助理，新创科技有限公司研发科学家，新加坡南洋理工大学化学和医药工程学院骨组织工程中心及新加坡皮肤研究学院研究员，新加坡南洋理工大学材料和科学工程学院高级研究员。回国后，任中国科学院大学温州研究院特聘研究员。在海外，曾参与或主导申获和执行过许多生物医药工程研发项目(总金额超过3千万人民币)。回国后作为项目负责人承担浙江省重点项目(尖兵领雁计划)。曾为多项医疗机械通过美国FDA，欧盟 CE和中国NMPA产品注册提供技术支持。建立和管理过4个研究中心或实验室。发表了46篇SCI论文, 2本合著书 (其中一书由生物医学组织工程学科奠基人- Robert Langer -美国三大科学院院士（美国科学院、美国工程院和医学院）和Joseph Vacanti教授主编，由全球近300余位科学家共同撰写) 和4项专利 。协助导师指导过12位博士研究和36名本科生毕业设计，教授大学本科课程4门。

1. Guo, Ting，Zhong, Fang，Wen, Feng，Liu, Peng，San Thian, Eng，Nie, Hemin，Li, Dan，Zhang, Rongkai，Ma, Chao，Lin, Nan，Wang, Zuyong (2022). Engineering of tenogenic patch scaffold with fibrous microtopography and reinforcement via uniaxial cold-drawing, Materials & Design, 217,110609.
2. Wang Yili, Wen Feng, Yao Xueting, Zeng Lulu, Wu Jiaming, He Qinhong, Li Huaqiong, Fang Lian (2021). Hybrid Hydrogel Composed of Hyaluronic Acid, Gelatin, and Extracellular Cartilage Matrix for Perforated TM Repair, Frontiers in Bioengineering and Biotechnology, 9.
3. S. Liu, C. Lau, K. Liang, F. Wen, SH. Teoh.(2021). Marine Collagen Scaffolds in Tissue Engineering, Current Opinion in Biotechnology, 92-103..
4. Liu, S., Wen, F., Muthukumaran, P., Rakshit, M., Lau, C.-S., Yu, N., et al. (2021). Self-Assembled Nanofibrous Marine Collagen Matrix Accelerates Healing of Full-Thickness Wounds. ACS Applied Bio Materials 4, 7044-7058. doi: 10.1021/acsabm.1c00685.
5. L. Suryani, J.K.R. Foo, A. Cardilla, Y. Dong, P. Muthukumaran, A. Hassanbhai, F. Wen, D.T. Simon, D. Iandolo, N. Yu, K.W. Ng, S.-H. Teoh, Effects of Pulsed Electromagnetic Field Intensity on Mesenchymal Stem Cells, Bioelectricity (2021) 2576-3105.
6. A. Srinivasan, N. Teo, K.J. Poon, P. Tiwari, A. Ravichandran, F. Wen, S.H. Teoh, T.C. Lim, Y.-C. Toh, Comparative Craniofacial Bone Regeneration Capacities of Mesenchymal Stem Cells Derived from Human Neural Crest Stem Cells and Bone Marrow, ACS Biomaterials Science & Engineering 7(1) (2021) 207-221.
7. Y. Dong, L. Suryani, X. Zhou, P. Muthukumaran, M. Rakshit, F. Yang, F. Wen, A.M. Hassanbhai, K. Parida, D.T. Simon, D. Iandolo, P.S. Lee, K.W. Ng, S.H. Teoh, Synergistic Effect of PVDF-Coated PCL-TCP Scaffolds and Pulsed Electromagnetic Field on Osteogenesis, International Journal of Molecular Sciences 22(12) (2021) 6438.
8. H. Yu, S.K. Chong, A.M. Hassanbhai, Y. Teng, G. Balachander, P. Muthukumaran, F. Wen, S.H. Teoh, Chapter 11 – Principles of bioreactor design for tissue engineering, in: R. Lanza, R. Langer, J.P. Vacanti, A. Atala (Eds.), Principles of Tissue Engineering (Fifth Edition), Academic Press2020, pp. 179-203.
9. QX. PAN, CY. GAO, YY. WANG, YL. WANG, C. MAO, Q. WANG, SN. ECONOMIDOU, D. DOUROUMIS, F. WEN, LP. TAN, HQ. LI. Investigation of bone reconstruction using an attenuated immunogenicity xenogenic composite scaffold fabricated by 3D printing. Bio-Design and Manufacturing. 3, 396–409 (2020)
10. WQ. ZHANG, ZY. WANG, C. XIE, XW. WANG, FF. LUO, MH. HONG, R. ZHOU, C. MA, N. LIN, JY. ZHANG, X. HU, JKY. CHAN, F. WEN*, YB. WANG. (2019). Scaffold with Micro/Macro‐Architecture for Myocardial Alignment Engineering into Complex 3D Cell Patterns, Advanced Healthcare Materials. 8, 1901015.
11. CS. LAU, AM. HASSANBHAI, F. WEN, DA. WANG, BT. GOH, N. YU and SH. TEOH. (2019). Evaluation of Decellularized Tilapia Skin as a Tissue Engineering Scaffold, Journal of Tissue Engineering and Regenerative Medicine. 13, 1779– 1791. https://doi.org/10.1002/term.2928.
12. ZY. WANG, WQ. ZHANG, C. XIE, F. WEN*, C. MA, N. LIN, ES. THIAN and XW. WANG. (2019). Geometric anisotropy on biomaterials surface for vascular scaffold design: engineering and biological advances. Journal of Physics: Materials. 2(3) 032003.
13. L. SURYANI, JH. TOO, AM. HASSANBHAI, F. WEN, DJ. LIN, N. YU and SH. TEOH. (2019). Effects of Electromagnetic Field on Proliferation, Differentiation and Mineralization of MC3T3 Cells, Tissue Engineering Part C: Methods, 25 (2): 114-125.
14. AM. HASSANBHAI, J. LIM, F. WEN, HL. CHEE, B. HO, SK. CHONG and SH. TEOH. (2018). Fabrication of a biodegradable scaffold with localized response to bacterial infections”. Merit Research Journal of Microbiology and Biological Sciences, 6(5), 54-68.
15. ZY. WANG, R. ZHOU, F. WEN, RK. ZHANG, L. REN, SH. TEOH and MH. HONG. (2018). Reliable laser fabrication: the quest for responsive biomaterials surface, Journal of Materials Chemistry B, 6, 3612-3631.
16. JCY. LIAO, M. HE, AWT. GAN, F. WEN, LP. TAN and AKS. CHONG. (2018). The Effects of Bi-functional Anti-adhesion Scaffolds on Flexor Tendon Healing in a Rabbit Model, Journal of Biomedical Materials Research. Part B: Applied Biomaterials.106(7), 2605-2614.
17. RAVICHANDRAN, F. WEN, J. LIM, SK. CHONG, JKY. CHAN and SH. TEOH. (2018). Biomimetic Fetal Rotation Bioreactor for Engineering Bone Tissues – Effect of Cyclic Strains on Upregulation of Osteogenic Gene Expression” Journal of Tissue Engineering and Regenerative Medicine, 1–12.
18. ZY WANG, F. WEN*, RK. ZHANG and QY. ZHANG. (2017). Modulated nitric oxide delivery in 3D biomaterials for vascular functionality. MRS Communications, 7(3), 348-360.
19. ZY. WANG, F. WEN, PN. LIM, QY. ZHANG, T. KONISHI, D. WANG, SH. TEOH and ES. THIAN. (2017). Nanomaterial scaffolds to regenerate musculoskeletal tissue: signals from within for neovessel formation. Drug Discovery Today, 22(9), 1385-1391.
20. AM. HASSANBHAI, CS. LAU, F. WEN, P. JAYARAMAN, BT. GOH, SH. TEOH and N. YU. (2017) In vivo immune responses of crosslinked electrospun tilapia collagen membrane, Tissue Engineering Part A, 23(19-20), 1110-1119.
21. RAVICHANDRAN, J. LIM, SK. CHONG, F. WEN, YC. LIU, JKY. CHAN and SH. TEOH. (2017). In vitro cyclic compressive loads potentiate early osteogenic events in engineered bone tissue, Journal of Biomedical Materials Research Part B: Applied Biomaterials, 105(8), 2366-2375
22. D. IANDOLO, A. RAVICHANDRAN, X. LIU, F. WEN, JKY. CHAN and M. BERGGREN. (2016). Development and Characterization of Organic Electronic Scaffolds for Bone Tissue Engineering. Advanced Healthcare Materials, 5(12):1505-1512.
23. HK. WONG, CRI. LAM, F. WEN, SK. CHONG, NS. TAN, JKY. CHAN and LP. TAN. (2016). Novel method to improve vascularization of tissue engineered constructs with biodegradable fibers. Biofabrication, 8(1):015004.
24. HQ. LI, F. WEN, H. CHEN, M. PAL, Y. LAI and AZ. ZHAO. (2016). Micropatterning Extracellular Matrix Proteins on Electrospun Fibrous Substrate Promote Human Mesenchymal Stem Cell Differentiation Toward Neurogenic Lineage. ACS Applied Materials and Interfaces, 8(1): 563-573.
25. YN. WU, F. WEN, SS. GOUK, EH. LEE and LL. KULESHOVA. (2015). Cryopreservation strategy for tissue engineering constructs consisting of human mesenhymal stem cells and hydrogel biomaterials. CryoLetters, 36(5): 325-335.
26. HQ. LI, F. WEN, XC. WANG and LP. TAN. (2015) Role of RhoA/Rho kinase signaling pathway in microgroove induced stem cell myogenic differentiation, Biointerphases, 10(2): 021003.
27. QY. ZHANG, ZY. WANG, F. WEN, L. REN, J. LI and SH. TEOH. (2015) Gelatin-Siloxane Nanoparticles to Deliver Nitric Oxide for Vascular Cell Regulation: Synthesis, Cytocompatibility and Cellular Responses 5), Journal of Biomedical Materials Research Part A, 103:929-938.
28. TT. ZHANG, F. WEN, YN. WU, GSH. GOH, ZG. GE, LP. TAN, HP. HUI and Z. YANG. (2015). Cross-talk between TGF-beta/SMAD and integrin signaling pathways in regulating hypertrophy of mesenchymal stem cell chondrogenesis under deferral dynamic compression, Biomaterials,38, 72-85.
29. TIJORE, F. WEN, CRI. LAM, CY. TAY and LP. TAN. (2014). Modulating Human Mesenchymal Stem Cell Plasticity using Micropatterning Technique, PLoS ONE, 9(11):e113043.
30. ZY. CAI, YL. TEO, J. LIM, YP. KOH, SQ. TAN, F. WEN, WK. LEE, CH. HING, YL. YAP, HJ. LEE, CN. LEE, SH. TEOH, J. LIM and TC. LIM. (2014). Bio-conjugated polycaprolactone membranes: a novel wound dressing, Archives of Plastic Surgery, 41(6):638-46.
31. TIJORE, S. HARIHARAN, HY. YU, CRI. LAM, F. WEN, CY. TAY, S. AHMED and LP. TAN. (2014). Investigating the Spatial Distribution of Integrin β1 in Patterned Human Mesenchymal Stem Cells Using Super-resolution Imaging (2014), ACS Applied Materials and Interfaces, 6(18):15686–15696.
32. F. WEN*, HK. WONG, CY. TAY, HY. YU, HQ. LI, T. YU, A. TIJORE, YC. BOEY, SS. VENKATRAMAN and LP. TAN. (2014). Induction of Myogenic Differentiation of Human Mesenchymal Stem Cells Cultured on Notch Agonist (Jagged-1) Modified Biodegradable Scaffold Surface, ACS Applied Materials and Interfaces, 6(3):1652-1661.
33. T. YU, CK. CHUA, CY. TAY, F. WEN, HY. YU, JK. CHAN, MS. CHONG, DT. LEONG and LP. TAN . (2013). A generic micropatterning platform to direct human mesenchymal stem cells from different origins towards myogenic differentiation, Macromolecular Bioscience, 13(6):799-807.
34. HY. YU, CY. TAY, M. PAL, WS. LEONG, HQ. LI, H. LI, F. WEN, DT. LEONG and LP. TAN. (2013). A Bio-inspired Platform to Modulate Myogenic Differentiation of Human Mesenchymal Stem Cells through Focal Adhesion Regulation, Advanced Healthcare Materials, 2(3):442-449.
35. HQ. LI, YS. WONG, F. WEN, KW. NG, GK. NG, SS. VENKATRAMAN, YC. BOEY and LP. TAN. (2012). Human Mesenchymal Stem Cell Behaviour on Direct Laser Micropatterned Electrospun Scaffolds with Hierarchical Structures, Macromolecular Bioscience, 13(3):299-310.
36. XW. WANG, R. MAGALHÃES, YN. WU, F. WEN, SS. GOUK, PF. WATSON, H. Yu and LL. KULESHOVA, Development of a modified vitrification strategy suitable for subsequent scale-up for hepatocyte preservation, Cryobiology 65(3) (2012) 289-300.
37. YS. WONG, CY. TAY, F. WEN, SS. VENKATRAMAN and LP. TAN. (2012). Engineered Polymeric Biomaterials for Tissue Engineering, Current Tissue Engineering, 1(1):41-53.
38. HY. YU, YS. LUI, SJ. XIONG, WS. LEONG, F. WEN, H. NURKAHFIANTO, S.RANA, DT. LEONG, KW. NG, and LP.TAN. (2012). Insights into the role of focal adhesion modulation in cardiac myogenic differentiation of hMSCs, Stem Cells and Development, 22(1): 136–147.
39. HQ. LI, F. WEN, YS. WONG, YC. BOEY, SS. VENKATRAMAN, DT. LEONG, KW. NG, KL. NG and LP. TAN. (2011). Direct laser machining-induced topographic pattern promotes up-regulation of myogenic markers in human mesenchymal stem cells (2011), Acta Biomaterialia, 8(2):531-539.
40. ZL. YUE, F. WEN, SJ. GAO, MY. ANG, PK. PALLATHADKA, LH. LIU and H. YU. (2010). Preparation of three-dimensional interconnected macroporous cellulosic hydrogels for soft tissue engineering, Biomaterials, 31(32):8141-52.
41. R. MAGALHÃES, A. KUMAR PR, F. WEN, X. ZHAO, H. YU and LL. KULESHOVA. (2009). The use of vitrification to preserve primary rat hepatocyte monolayer on collagen-coated poly(ethylene-terephthalate) surfaces for a hybrid liver support system, Biomaterials, 30(25):4136-4142.
42. F. WEN*, R. MAGALHÃES, SS. GOUK, G. BHAKTA, KH. LEE, DW. HUTMACHER and LL. KULESHOVA. (2009). Vitreous Cryopreservation of Nanofibrous Tissue-Engineered Constructs Generated Using Mesenchymal Stromal Cells, Tissue Engineering Part C: Materials, 15(1):105-114.
43. F. WEN*, S. CHANG, YC. TOH, T. AROOZ, L. ZHUO, SH. TEOH and H. YU. (2008). Development of dual-compartment perfusion bioreactor for serial coculture of hepatocytes and stellate cells in poly(lactic-co-glycolic acid)-collagen scaffolds, Journal of Biomedical Materials Research Part B Applied Biomaterials, 87(1):154-162.
44. YN. DU, R. HAN, F. WEN, SS. NG, L. XIA, T. WOHLAND, HL. LEO and H. YU. (2008). Synthetic sandwich culture of 3D hepatocyte monolayer, Biomaterials, 29(3):290-301.
45. G. BHAKTA, KH. LEE, R. MAGALHÃES, F. WEN, SS. GOUK, DW. HUTMACHER and LL. KULESHOVA.(2008). Cryoreservation of alginate-fibrin beads involving bone marrow derived mesenchymal stromal cells by vitrification, Biomaterials, 30(3):336-343.
46. F. WEN*, S. CHANG, YC. TOH, SH. TEOH and H. YU. (2007). Development of poly (lactic-co-glycolic acid)-collagen scaffolds for tissue engineering, Materials Science and Engineering: C, 27(2):285–292.

1. Method and Apparatus for In-Vitro Tissue Cultivation， WO2018/132071 A1， 2018.7
2. Forming Porous Scaffold from Cellulose Derivatives， EP2234655B1， 2018.12
3. 脱细胞基质及其制备方法， 202210686839.X, 2022.6
4. Hydrogel Scaffolds And Uses Thereof， PCT/SG2022/050234， 2022.9

1.Hanry Yu, Seow Khoon Chong, Ammar Mansoor Hassanbhai, Yao Teng, Gowri Balachander, Padmalosini Muthukumaran, F. Wen, Swee Hin Teoh. (2020). Chapter 11 – Principles of bioreactor design for tissue engineering, In Principles of Tissue Engineering (Fifth Edition), Academic Press, p179-203.
2.F. Wen*, CS. Lau, J. Lim, YW. Liao, SH. Teoh and SK. Chong. (2016). Surface modification of tissue engineering scaffolds. In Polymeric Biomaterials for Tissue Regeneration: from Surface/Interface Design to 3D Constructs. Spring.p123-150.

1. FL. CHEN, F. WEN, DW. HUTMACHER and SH. TEOH. “Stiffness of Polycaprolactone Influences Chondrocytes Proliferation”. TESI 2003. Orlando, USA.
2. F. WEN, YM. KHONG, YN. DU, ZL. YUE, K. IOURI, SH. TEOH and H. YU. “Surface Modification of Bulky Tissue Engineering Scaffold through Gamma Irradiation”. Keystone Symposia (Tissue Engineering and Development Biology) 2007, Salt Lake City, USA.
3. F. WEN, HQ. LI, HY. YU, CY. TAY, HK. WONG, YS. WONG and LP. TAN. “Inducing Human Mesenchymal Stem Cells towards Cardiomyogenic Differentiation through Grafting Protein Peptides on the Surface of Cell Substrate”. TERMIS -NA 2011, Huston, USA.
4. JCY. LIAO, M. HE, AWT. GAN, F. WEN, LP. TAN and AKS. CHONG. “Effects of Bi-functional Anti-adhesion Scaffolds on Flexor Tendon Healing in a Rabbit Model”. ASSH Seattle 2015, Seattle, USA.
5. F. WEN, N. CHANCHAREONSOOK, WY. LIU, N. YU, AM. HASSANBHAI, J. LIM, BT. GOH and SH. TEOH. “Encapsulation of scaffolds in hydrogel beads with mesenchymal stem cells for rabbit calvarial bone defect repair”. WBC 2016, Montreal, Canada.
6. CS. LAU, AM. HASSANBHAI, F. WEN, P. JAYARAMAN, DA. WANG, N. YU and SH. TEOH. “A comparative study on the use of tilapia collagen membranes for guided bone regeneration”. SFB 2017, Minneapolis, USA.
7. SH. TEOH, L. SURYANI, F. WEN, P. MUTHUKUMARAN, M. RAKSHIT, AM. HASSANBHAI, KW. NG, YB. DONG, KY. SEE, KR. LI, D. IANDOLO, DT. SIMON, A. RAVICHANDRAN, N. CHANCHAREONSOOK and BT. GOH. “Development of biaxial bioreactor with mechanical and electromagnetic signals for bone tissue engineering” TERMIS-AP 2019, Brisbane, Australia.
8. F. WEN, C.S. LAU, P. MUTHUKUMARAN, A.M. HASSANBHAI, N. YU, S.H. TEOH. “Decellularization of tilapia skin for wound healing repair” Singapore Fish Meeting 2019, Singapore.
9. Nattharee Chanchareonsook，余娜，李花琼，温峰。“利用3D打印支架结合干细胞水凝胶修复兔颅骨缺损” 2022 高分子 3D 打印材料高峰论坛，中国， 宁波。

2023/1-至今 创新脱细胞技术开发慢性创面修复高端医用敷料，浙江省科技厅及浙江省医鼎敷料有限公司资助，750万人民币, 项目负责人。
2021/6-至今 磁场对动态培养中的干细胞生长分化影响，国科温州研究院资助，30万人民币, 项目负责人。
2019/2-2021/6 生物材料的增材制造（Additive Manufacturing for Biological Materials）, RIE2020 资助 ,约323万人民币, 技术负责人。
2018/1-2021/6 脱细胞鱼皮作为伤口敷料，刺激伤口愈合（Decellularized fish skin as wound dressing to stimulate wound healing）,SRIS 资助约230万人民币, 技术负责人。
2017/6-2021/6 在新型动态电磁生物反应器中的培养骨移植体（Engineering Bone Grafts In A Novel Dynamic Electromagnetic Bioreactor）, MOE资助约569万人民币, 技术负责人。
2014/3-2018/3 牙科转化骨组织工程（Translational Bone Tissue Engineering For Dentistry）, NTU资助约265万人民币, 技术负责人。
2008/8-2013/7 可生物降解的心血管植入体（Biodegradable Cardiovascular Implant）, NRF资助约363万人民币, 技术负责人。

1. 生物组织工程支架的表面改性对细胞生长和分化影响。
2. 3D打印组织工程可降解支架在骨缺陷动物模型中的修复作用。
3. 干细胞及其组织工程支架载体在具有电磁和机械诱导的生物反应器中培养, 分化。
4. 鱼胶原蛋白提取及其在骨缺损和皮肤伤口的修复作用。
5. 脱细胞化组织材料制备以及在生命组织工程的应用。
6. 细胞源人造猪肉的制备