Yili Ding received the Ph. D degree in carbohydrate chemistry, got training in world famous carbohydrate laboratories including J. Dafeye’s lab. in CNRS in France, Ole Hindsgaul’s lab. in University of Alberta in Canada and Roy L. Whistler’s lab. in Purdue University in USA, did the research work in top institutes including Stanford Burnham Instidute and the Scripps Research Institute, and worked in big pharmaceutical companies including Valeant pharmaceutical in USA and ISIS pharmaceuticals in USA, achieved the chemical synthesis of heptasaccharides with sulfur linkage, as the phytoalexin elicitors, in 43 chemistry steps, which are the largest sulfur linked synthetic oligosaccharides to date (Eur. J. Org. Chem., 1999, 1999(5): 1143-1152), developed the random glycosylation approach to synthesize the oligosaccharide library, which was the first example of using combinatorial methods to produce oligosaccharides and 1000 times faster than traditional methods (Glycoimmunology, Advances in Experimental Medicine and Biology, Plenum Press, New York, 1995, 261-270; Angew. Chem., Int. Ed. Engl., 1995, 34(23-24): 2720-2722; European J. Org. Chem., 2020, 2020(12): 1782-1916), as another first achievement, completed the chemical synthesis of the heterocycle substituted aminoglycosides as potential antibiotics (Org. Lett., 2001, 3(11): 1621–1623; Angew. Chem., Int. Ed. Engl., 2003, 42(29): 3409-3412), completed the first-ever chemical synthesis of the disaccharides of 5-aza sugar (mannojirimycine) and 5-thio glucose or 1-thio glucose (Bioorg. Med. Chem. Lett., 1998, 8(10): 1215-1220), achieved the chemical synthesis of a trimer of sialic acid-related LacNAc pentasaccharide for the first time, which is more difficult synthetically when compared with other comparable oligosaccharides (Bioorg. Med. Chem. Lett., 1998, 8: 1903-1908), for the first time, established a general strategy for synthesizing 2-deoxy ribosyl disaccharide nucleosides in the synthetic investigation of the anti-tumor compound ISIS 183750 (Tetrahedron, 2017, 73(27–28): 3848-3852), developed a new methodology by using the thio-alkyl group as a temporary protection group for the α, β-unsaturated cyclohexane-1,3- diketone derivative during the reaction with an ethyl-organometallic reagent to get the desired Michael addition product, and based on this new methodology, an analog of Tipranavir with a 1,3-cyclohexanedione ring was synthesized as a potential HIV drug (Letter in Organic Chemistry, 2009, 6(2): 130-133), as one of the most difficult generic drugsIn another first achievement, completed the chemical synthesis of the heterocycle substituted aminoglycosides as potential antibiotics (Org. Lett., 2001, 3(11): 1621–1623; Angew. Chem., Int. Ed. Engl., 2003, 42(29): 3409-3412). completed the first-ever chemical synthesis of the disaccharides of 5-aza sugar (mannojirimycine) and 5-thio glucose or 1-thio glucose (Bioorg. Med. Chem. Lett., 1998, 8(10): 1215-1220). achieved the chemical synthesis of a trimer of sialic acid-related LacNAc pentasaccharide for the first time, which is more difficult synthetically when compared with other comparable oligosaccharides (Bioorg. Med. Chem. Lett., 1998, 8: 1903-1908). for the first time, established a general strategy for synthesizing 2-deoxy ribosyl disaccharide nucleosides in the synthetic investigation of the anti-tumor compound ISIS 183750 (Tetrahedron, 2017, 73(27–28): 3848-3852). developed a new methodology by using the thio-alkyl group as a temporary protection group for the α, β-unsaturated cyclohexane-1,3-diketone derivative during the reaction with an ethyl-organometallic reagent to get the desired Michael addition product, and based on this new methodology, an analog of Tipranavir with a 1,3-cyclohexanedione ring was synthesized as a potential HIV drug (Letter in Organic Chemistry, 2009, 6(2): 130-133), synthesized the Fondaparinux as one of the most difficult generic drugs by using the most efficient strategy on a kilogram scale by combining the advantages of Alchemia and Sanofi methods (Bioorganic & Medicinal Chemistry Letters, 2017, 27(11): 2424-2427; Journal of Chemistry, 2019, 2019, ID 9545297), published the first disubstituted beta cyclodextrin derivative 6A,6D-1-thio beta-D-galactose, 1-thio b-D-lactose-beta cyclodextrin as a liver cancer drug carrier (Carbohydrate Polymers, 2018, 181: 957-963), approved by the Ministry of Education in 2001, and hired by Zhejiang University as a Distinguished Professor of the "Cheung Kong Scholars Program”,   hired as "Pearl River Distinguished Professor" by Sun Yat-sen University in 2005; hired as a "chair professor" by Shandong University in 2006,  selected as "Fourth Batch of Hundred Talents Plan" of Hebei Province in 2014, selected as the Shijiazhuang Science and Technology Leader in 2014, selected by Top-notch young talents of Pearl River Talent Program of Guangdong Province as overseas expert in 2017.

1.Study on carbohydrate related drugs

2.Solve the solubility, targeting and stability issues of anti-liver cancer drugs in order to find more efficient liver cancer drugs

1. Ding, Y., Cui, W., Pang, Y., Vara Prasad, C. V. N. S., & Wang, B. (2021). Preparation of inclusion complex of praziquantel with 2-hydroxypropyl-β-cyclodextrin and pharmacokinetic property improvement. Arabian Journal of Chemistry, 14(9), 103307. https://doi.org/10.1016/j.arabjc.2021.103307

2. Ding, Y., Cui, W., Vara Prasad, C. V. N. S., & Wang, B. (2021). Design and Synthesis of Lactose, Galactose and Cholic Acid Related Dual Conjugated Chitosan Derivatives as Potential Anti Liver Cancer Drug Carriers. Polymers, 13(17), 2939. https://doi.org/10.3390/polym13172939

3. Ding, Y., Pang, Y., Vara Prasad, C. V. N. S., & Wang, B. (2020). Formation of inclusion complex of enrofloxacin with 2-hydroxypropyl-β-cyclodextrin. Drug Delivery, 27(1), 334–343. https://doi.org/10.1080/10717544.2020.1724210

4. Ding, Y., Vara Prasad, C. V. N. S., Ding, C., & Wang, B. (2018). Synthesis of carbohydrate conjugated 6A,6D-bifunctionalized β cyclodextrin derivatives as potential liver cancer drug carriers. Carbohydrate Polymers, 181, 957–963. https://doi.org/10.1016/j.carbpol.2017.11.054

5. Ding, Y., Yu, B., Zhang, J., Ding, C., Zhang, Z., Xu, S., Li, L., & Yu, H. (2022). Tilmicosin/γ-Cyclodextrin complexation through supercritical carbon dioxide assistance and its pharmacokinetic and antibacterial study. European Journal of Pharmaceutics and Biopharmaceutics, 181, 104–112. https://doi.org/10.1016/j.ejpb.2022.10.024

1. “Innovation and Entrepre- neurship Team Project” of the Blue Ocean Talents Program in Shishan Town, Nanhai District, Foshan City, 2 millions; by Guangdong Province, for a period of three years (2019–2021, the ninth batch, funding number: 201804300016), the ninth batch, funding number: 201804300016)
2. Guang Dong R&D projects in key areas (19BllO209005, from 2019, July, 1, to 2023, June, 30), 8 millions.
3. Top-notch young talents of Pearl River Talent Program of Guangdong Province as overseas expert ,0.15 million.
4. Zhejiang High-level Talent Research Fund, 2022, 3.5 millions.